The circadian system of c-fos deficient mice

We examined the role of c-fos in the synchronization of circadian rhythms to environmental light cycles using a line of gene-targeted mice carrying a null mutation at this locus. Circadian locomotor rhythms in mutants had similar periods as wild-type controls but took significantly longer than contr...

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Bibliographic Details
Published in:Journal of Comparative Physiology A 1996-04, Vol.178 (4), p.563-570
Main Authors: Honrado, G.I., Johnson, RandallS, Golombek, D.A., Spiegelman, B.M., Papaioannou, V.E., Ralph, M.R.
Format: Article
Language:English
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Summary:We examined the role of c-fos in the synchronization of circadian rhythms to environmental light cycles using a line of gene-targeted mice carrying a null mutation at this locus. Circadian locomotor rhythms in mutants had similar periods as wild-type controls but took significantly longer than controls to entrain to 12:12 light-dark cycles. Light-induced phase shifts of rhythms in constant dark were attenuated in mutants although the circadian timing of phase delays and advances was not changed. A functional retinohypothalamic projection was indicated from behavioral results and light-induced jun-B expression in the SCN. The results indicate that while c-fos activation is not an absolute requirement for rhythm generation nor photic responses, it is required for normal entrainment of the mammalian biological clock.
ISSN:0340-7594
1432-1351
DOI:10.1007/BF00190186