Loading…
Generation of calcium oscillations in fibroblasts by positive feedback between calcium and IP sub(3)
In this study, Ca super(2+) was found to stimulate its own release in REF52 fibroblasts primed by mitogens plus depolarization. However, unlike Ca super(2+) release in muscle and nerve cells, this amplification was insensitive to caffeine or ryanodine and required hormone receptor occupancy and func...
Saved in:
Published in: | Science (American Association for the Advancement of Science) 1991-01, Vol.251 (4989), p.75-78 |
---|---|
Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | In this study, Ca super(2+) was found to stimulate its own release in REF52 fibroblasts primed by mitogens plus depolarization. However, unlike Ca super(2+) release in muscle and nerve cells, this amplification was insensitive to caffeine or ryanodine and required hormone receptor occupancy and functional IP sub(3) receptors. Oscillations in (Ca super(2+)) sub(i) were accompanied by oscillations in IP sub(3) concentration but did not require functional protein kinase C. Therefore, the dominant feedback mechanism in this cell type appears to be Ca super(2+) stimulation of phospholipase C once this enzyme has been activated by hormone receptors. |
---|---|
ISSN: | 0036-8075 |