The Glycosylphosphatidylinositol-anchored Surface Glycoprotein Thy-1 Is a Receptor for the Channel-forming Toxin Aerolysin

Aerolysin is a channel-forming protein secreted by virulent Aeromonas spp. Some eucaryotic cells, including T-lymphocytes, are sensitive to very low concentrations of the toxin (

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Bibliographic Details
Published in:The Journal of biological chemistry 1997-05, Vol.272 (18), p.12170-12174
Main Authors: Nelson, K L, Raja, S M, Buckley, J T
Format: Article
Language:English
Subjects:
Aeromonas
Animals
Bacterial Toxins - metabolism
Bacterial Toxins - pharmacology
Brain - metabolism
Glycosylphosphatidylinositols - metabolism
Hemolysin Proteins - metabolism
Ion Channels - physiology
Kinetics
Liposomes
Lymphoma
Mice
Molecular Weight
Organ Specificity
Phosphatidylinositol Diacylglycerol-Lyase
Phosphoinositide Phospholipase C
Phosphoric Diester Hydrolases
Pore Forming Cytotoxic Proteins
T-Lymphocytes
Thy-1 Antigens - metabolism
Thymoma
Thymus Gland - metabolism
Thymus Neoplasms
Tumor Cells, Cultured
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Description
Summary:Aerolysin is a channel-forming protein secreted by virulent Aeromonas spp. Some eucaryotic cells, including T-lymphocytes, are sensitive to very low concentrations of the toxin (
ISSN:0021-9258
1083-351X
DOI:10.1074/jbc.272.18.12170