Attempts to use liposomes and RBC ghosts as vectors in drug and antisense therapy of virus infection

Selective targeting of drugs or oligonucleotide for the treatment of viral diseases or cancer is the objective of new strategies that pursue therapy optimization and reduction of toxicity. In this work we report two protocols based on encapsulation of antihuman immunodeficiency virus drugs within ta...

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Bibliographic Details
Published in:Research in virology (Paris) 1997, Vol.148 (2), p.177-180
Main Authors: Grimaldi, S., Lisi, A., Pozzi, D., Santoro, N.
Format: Article
Language:English
Subjects:
Adenine - administration & dosage
Adenine - analogs & derivatives
Adenine - pharmacology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antisense delivery
Antiviral agents
Antiviral Agents - administration & dosage
Antiviral Agents - pharmacology
Antiviral therapy
Biological and medical sciences
Cells, Cultured
Drug Carriers
Drug delivery
Erythrocyte Membrane
HIV
HIV-1 - drug effects
Human immunodeficiency virus
Humans
Liposome
Liposomes
Medical sciences
Oligonucleotides, Antisense - administration & dosage
Oligonucleotides, Antisense - pharmacology
Organophosphonates
Pharmacology. Drug treatments
RBC
Virus Diseases - drug therapy
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Summary:Selective targeting of drugs or oligonucleotide for the treatment of viral diseases or cancer is the objective of new strategies that pursue therapy optimization and reduction of toxicity. In this work we report two protocols based on encapsulation of antihuman immunodeficiency virus drugs within targeted liposomes or erythrocytes. Both have been shown to be effective for the specific delivery of drugs or oligonucleotide in the treatment of viral infection.
ISSN:0923-2516
DOI:10.1016/S0923-2516(97)89906-2