Jineol, a Cytotoxic Alkaloid from the Centipede Scolopendra subspinipes

Jineol (1), a new quinoline alkaloid, was isolated from the centipede Scolopendra subspinipes, and its structure was elucidated by 2D NMR experiments. Jineol exhibited modest cytotoxic activity in vitro against the growth of human tumor cell lines:  A-549, SKOV-3, SK-Mel-2, XF-498, and HCT-15 cells....

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 1996-08, Vol.59 (8), p.777-779
Main Authors: Moon, Surk-Sik, Cho, Namsun, Shin, Jongheon, Seo, Youngwan, Lee, Chong Ock, Choi, Sang Un
Format: Article
Language:English
Subjects:
AGENTES ANTINEOPLASTICOS
ALCALOIDE QUINOLIQUE
ALCALOIDES DE LA QUINOLINA
ANTINEOPLASTIC AGENTS
Biological and medical sciences
CHEMICAL COMPOSITION
CHEMICAL STRUCTURE
CHILOPODA
COMPOSICION QUIMICA
COMPOSITION CHIMIQUE
CYTOTOXIC COMPOUNDS
ESPECTROMETRIA
ESTRUCTURA QUIMICA
General pharmacology
HUMAN TUMOR CELL LINES
KOREA DEMOCRATIC PEOPLE'S REPUBLIC
KOREA REPUBLIC
Medical sciences
MEDICAMENT CYTOSTATIQUE
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
QUINOLINE ALKALOIDS
REPUBLICA DE COREA
REPUBLICA POPULAR DEM DE COREA
REPUBLIQUE DE COREE
REPUBLIQUE DEM ET POP DE COREE
Scolopendridae
SPECTRAL ANALYSIS
SPECTROMETRIE
SPECTROMETRY
STRUCTURE CHIMIQUE
SUBSTANCE TOXIQUE
SUSTANCIAS TOXICAS
TOXIC SUBSTANCES
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Summary:Jineol (1), a new quinoline alkaloid, was isolated from the centipede Scolopendra subspinipes, and its structure was elucidated by 2D NMR experiments. Jineol exhibited modest cytotoxic activity in vitro against the growth of human tumor cell lines:  A-549, SKOV-3, SK-Mel-2, XF-498, and HCT-15 cells.
ISSN:0163-3864
1520-6025
DOI:10.1021/np960188t