Differential effects of chronic lorazepam and alprazolam on benzodiazepine binding and GABA sub(A)-receptor function

Chronic benzodiazepine administration has been associated with tolerance and with downregulation of gamma -aminobutyric acid sub(A) (GABA sub(A))-receptor binding and function. However, effects of individual benzodiazepines on brain regions have varied. These data suggest that the effects of chronic...

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Bibliographic Details
Published in:British journal of pharmacology 1990-01, Vol.101 (4), p.839-842
Main Authors: Galpern, W R, Miller, L G, Greenblatt, D J, Shader, R I
Format: Article
Language:English
Online Access:Get full text
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Summary:Chronic benzodiazepine administration has been associated with tolerance and with downregulation of gamma -aminobutyric acid sub(A) (GABA sub(A))-receptor binding and function. However, effects of individual benzodiazepines on brain regions have varied. These data suggest that the effects of chronic benzodiazepine administration on the GABA sub(A)-receptor may be both region-specific and receptor subtype-specific.
ISSN:0007-1188