Supercritical Fluid Extraction of Strychnine Using Two Different Sequential Organic Modifiers

• Published in: Journal of agricultural and food chemistry 1995-05, Vol.43 (5), p.1208-1211
• Main Authors: Kelly, Kevin L, Johnston, John J
• Format: Article
• Language: English
• Subjects: AVENA SATIVA; Biological and medical sciences; DIOXIDO DE CARBONO; DIOXYDE DE CARBONE; ESTRICNINA; EXTRACCION SUPERCRITICO DE FLUIDO; EXTRACTION AU FLUIDE SUPERCRITIQUE; Fundamental and applied biological sciences. Psychology; Medically important nuisances and vectors, pests of stored products and materials: population survey and control; Pests of stored products; PRESION; PRESSION; STRYCHNINE; Vertebrates
• ISSN: 0021-8561; 1520-5118
• DOI: 10.1021/jf00053a016

Carbon dioxide supercritical fluid extraction (SFE) of strychnine from oat grain bait was accomplished using a methanol modifier during static extraction and a chloroform modifier during dynamic extraction. Extraction efficiency was better than with the use of either modifier alone. Analysis time, strychnine recoveries (82%), and reproducibility (SD = 7.8%) were not significantly different from the 85% recovery and 5.4% SD obtained with a routinely used organic solvent/solid extraction method. The supercritical fluid extraction method generated no hazardous waste as compared to the solvent/solid extraction method, which produced 50 mL of hazardous waste per sample. This two solvent modifier SFE method resulted in better precision and recovery of strychnine from oat bait than other reported SFE methods for the recovery of pesticides from treated grains