Immunogenicity of influenza vaccine (1993–1994 winter season) in HIV-seropositive and -seronegative ex-intravenous drug users

• Published in: Vaccine 1997, Vol.15 (1), p.97-102
• Main Authors: Iorio, Anna M., Alatri, Adriano, Francisci, Daniela, Preziosi, Roberta, Neri, Mariella, Donatelli, Isabella, Castrucci, Maria R., Biasio, Luigi R., Tascini, Carlo, Iapoce, Riccardo, Pierucci, Piero, Baldelli, Franco
• Format: Article
• Language: English
• Subjects: Adult; Antibodies, Viral - biosynthesis; Biological and medical sciences; CD4 Lymphocyte Count; drug abuse; Female; Fundamental and applied biological sciences. Psychology; HIV Antibodies - blood; HIV Core Protein p24 - blood; HIV infection; HIV Infections - complications; HIV Infections - immunology; HIV Seronegativity - immunology; human immunodeficiency virus; Humans; Immunization, Secondary; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Influenza vaccine; Influenza Vaccines - immunology; influenza virus; Male; Medical sciences; Microbiology; Middle Aged; Substance Abuse, Intravenous - complications; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies; Virology
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/S0264-410X(96)00057-6

The humoral response (haemagglutination inhibiting antibodies) to trivalent split influenza vaccine for the 1993–1994 winter season (A/Beijing/32/92 (H3N2), A/Singapore/6/86 (H1N1) and B/Panama/45/90) was evaluated in a group of young HIV-seropositive ex-intravenous heroin users and compared with responses measured in HIV-seronegative individuals with a similar history. HIV-negative volunteers showed an overall positive response suggesting that previous heroin use did not influence their humoral response to influenza vaccine. Comparable results were obtained in HIV-positive subjects with CD4+ lymphocyte counts >500 μl −1, whereas impaired reactivity was found in HIV-positive volunteers with CD4+ counts