Nature of the endogenous pyrogen (EP) induced by influenza viruses: lack of correlation between EP levels and content of the known pyrogenic cytokines, interleukin 1, interleukin 6 and tumour necrosis factor

The 1 Microbial Molecular Genetics and Cell Biology Research Group, School of Biological Sciences and 2 The Medical School, University of Birmingham B15 2TT and 3 Division of Immunology, National Institute for Biological Standards and Control, South Mimms, Potters Bar, Hertfordshire EN6 3QG, U.K. Fe...

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Bibliographic Details
Published in:Journal of general virology 1991-03, Vol.72 (3), p.705-709
Main Authors: Jakeman, Kenneth J, Bird, Christopher R, Thorpe, Robin, Smith, Harry, Sweet, Clive
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Biological Assay
Ferrets
Fever - etiology
Fundamental and applied biological sciences. Psychology
Interleukin-1 - biosynthesis
Interleukin-1 - physiology
Interleukin-6 - biosynthesis
Interleukin-6 - physiology
Leukocytes - immunology
Microbiology
Orthomyxoviridae - physiology
Orthomyxoviridae Infections - metabolism
Pyrogens - biosynthesis
Pyrogens - physiology
Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains
Sonication
Tumor Necrosis Factor-alpha - biosynthesis
Tumor Necrosis Factor-alpha - physiology
Virology
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Summary:The 1 Microbial Molecular Genetics and Cell Biology Research Group, School of Biological Sciences and 2 The Medical School, University of Birmingham B15 2TT and 3 Division of Immunology, National Institute for Biological Standards and Control, South Mimms, Potters Bar, Hertfordshire EN6 3QG, U.K. Fever in influenza results from the release of endogenous pyrogen (EP) following virus-phagocyte interaction and its level correlates with the differing virulence of virus strains. However, the different levels of fever produced in ferrets by intracardial inoculation of EP obtained from the interaction of different virus strains with ferret or human phagocytes did not correlate with the levels of interleukin 1 (IL-1), IL-6 or tumour necrosis factor in the same samples as assayed by conventional in vitro methods. Hence, the EP produced by influenza virus appears to be different to these cytokines. Received 1 October 1990; accepted 3 December 1990.
ISSN:0022-1317
1465-2099
DOI:10.1099/0022-1317-72-3-705