Pex14p, a Peroxisomal Membrane Protein Binding Both Receptors of the Two PTS-Dependent Import Pathways

Pex14p, an S. cerevisiae peroxin, is attached to the outer face of the peroxisomal membrane and is a component of the protein import machinery. Pex14p interacts with both the PTS1 and PTS2 receptors. It is the only known peroxisomal membrane protein that binds the PTS2 receptor and might thus mediat...

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Bibliographic Details
Published in:Cell 1997-04, Vol.89 (1), p.83-92
Main Authors: Albertini, Markus, Rehling, Peter, Erdmann, Ralf, Girzalsky, Wolfgang, Kiel, Jan A.K.W, Veenhuis, Marten, Kunau, Wolf-H
Format: Article
Language:English
Subjects:
Biological Transport - physiology
Carrier Proteins
Cytoplasm - metabolism
Fungal Proteins - genetics
Fungal Proteins - isolation & purification
Fungal Proteins - metabolism
Gene Deletion
Gene Expression Regulation, Fungal - physiology
Membrane Proteins - genetics
Membrane Proteins - isolation & purification
Membrane Proteins - metabolism
Membrane Transport Proteins
Microbodies - chemistry
Microbodies - metabolism
Molecular Sequence Data
Mutagenesis - physiology
Peroxins
Peroxisomal Targeting Signal 2 Receptor
Peroxisome-Targeting Signal 1 Receptor
Protein Binding - physiology
Receptors, Cytoplasmic and Nuclear - metabolism
Repressor Proteins
Saccharomyces cerevisiae
Saccharomyces cerevisiae - chemistry
Saccharomyces cerevisiae - metabolism
Saccharomyces cerevisiae - ultrastructure
Saccharomyces cerevisiae Proteins
Sequence Homology, Amino Acid
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Summary:Pex14p, an S. cerevisiae peroxin, is attached to the outer face of the peroxisomal membrane and is a component of the protein import machinery. Pex14p interacts with both the PTS1 and PTS2 receptors. It is the only known peroxisomal membrane protein that binds the PTS2 receptor and might thus mediate the membrane docking event of PTS2-dependent protein import. These results suggest that the two import pathways overlap and, furthermore, that Pex14p represents the point of convergence. Pex14p also interacts with two other membrane-bound peroxins including Pex13p, another binding protein for the PTS1 receptor. The data presented here are consistent with the idea of a common translocation machinery for both PTS-dependent protein import pathways in the peroxisomal membrane.
ISSN:0092-8674
1097-4172
DOI:10.1016/S0092-8674(00)80185-3