Loading…
Lectin-carbohydrate interaction in the immune system
The immune system consists of various types of cells and molecules that specifically interact with each other to initiate the host defense mechanism. Recent studies have shown that carbohydrates and lectins (carbohydrate-binding proteins) play an essential role in mediating such interactions. Both l...
Saved in:
Published in: | Veterinary immunology and immunopathology 1996-12, Vol.55 (1), p.205-223 |
---|---|
Main Authors: | , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c476t-6f3c4efe576f2b3bd34d175957880b0fb41fff18135a2496a7446021e9637d4a3 |
---|---|
cites | cdi_FETCH-LOGICAL-c476t-6f3c4efe576f2b3bd34d175957880b0fb41fff18135a2496a7446021e9637d4a3 |
container_end_page | 223 |
container_issue | 1 |
container_start_page | 205 |
container_title | Veterinary immunology and immunopathology |
container_volume | 55 |
creator | Ni, Y. Tizard, I. |
description | The immune system consists of various types of cells and molecules that specifically interact with each other to initiate the host defense mechanism. Recent studies have shown that carbohydrates and lectins (carbohydrate-binding proteins) play an essential role in mediating such interactions. Both lectins and carbohydrates are widely distributed in the mammalian tissues as well as in microorganisms. Carbohydrates, due to their chemical nature, can potentially form structures that are more variable than proteins and nucleic acids. Lectins can exist in either soluble or cell-associated form, and although overall structures vary, invariably possess carbohydrate-recognition domains (CRD) with various specificities. The interaction between lectins and carbohydrates have been shown to be involved in such activities as opsonization of microorganisms, phagocytosis, cell adhesion and migration, cell activation and differentiation, and apoptosis. The number of lectins identified in the immune system is increasing at a rapid pace. The development in this area has opened a new aspect in studying the immune system, and at the same time, provided new therapeutic routes for the treatment and prevention of disease. |
doi_str_mv | 10.1016/S0165-2427(96)05718-2 |
format | article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_15966581</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0165242796057182</els_id><sourcerecordid>15966581</sourcerecordid><originalsourceid>FETCH-LOGICAL-c476t-6f3c4efe576f2b3bd34d175957880b0fb41fff18135a2496a7446021e9637d4a3</originalsourceid><addsrcrecordid>eNqFkElLA0EQhRtRYoz-ASGQk-hhtPflJBLcIOhBPTc9M9WmJTOj3RMh_97OQq5eqor36lXBh9CY4GuCibx5y0UUlFN1aeQVForogh6gIdGKFVQwfoiG-5VjdJLSF8ZYGK0HaGAw4YzoIeIzqPrQFpWLZTdf1dH1MAltD9FlvWvzPOnnWWqaZQuTtEo9NKfoyLtFgrNdH6GPh_v36VMxe318nt7Nioor2RfSs4qDB6GkpyUra8ZrooQRSmtcYl9y4r0nmjDhKDfSKc4lpgSMZKrmjo3Qxfbud-x-lpB624RUwWLhWuiWyRJhpBQ5P0Jiu1jFLqUI3n7H0Li4sgTbNS27oWXXKKyRdkPL0pwb7x4sywbqfWqHJ_vnW9-7zrrPGJJ9mRmFGdUim7dbEzKC3wDRpipAW0EdYoZq6y788_4PYZaAjg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>15966581</pqid></control><display><type>article</type><title>Lectin-carbohydrate interaction in the immune system</title><source>Elsevier:Jisc Collections:Elsevier Read and Publish Agreement 2022-2024:Freedom Collection (Reading list)</source><creator>Ni, Y. ; Tizard, I.</creator><creatorcontrib>Ni, Y. ; Tizard, I.</creatorcontrib><description>The immune system consists of various types of cells and molecules that specifically interact with each other to initiate the host defense mechanism. Recent studies have shown that carbohydrates and lectins (carbohydrate-binding proteins) play an essential role in mediating such interactions. Both lectins and carbohydrates are widely distributed in the mammalian tissues as well as in microorganisms. Carbohydrates, due to their chemical nature, can potentially form structures that are more variable than proteins and nucleic acids. Lectins can exist in either soluble or cell-associated form, and although overall structures vary, invariably possess carbohydrate-recognition domains (CRD) with various specificities. The interaction between lectins and carbohydrates have been shown to be involved in such activities as opsonization of microorganisms, phagocytosis, cell adhesion and migration, cell activation and differentiation, and apoptosis. The number of lectins identified in the immune system is increasing at a rapid pace. The development in this area has opened a new aspect in studying the immune system, and at the same time, provided new therapeutic routes for the treatment and prevention of disease.</description><identifier>ISSN: 0165-2427</identifier><identifier>EISSN: 1873-2534</identifier><identifier>DOI: 10.1016/S0165-2427(96)05718-2</identifier><identifier>PMID: 9014318</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; CARBOHIDRATOS ; CARBOHYDRATES ; Carbohydrates - chemistry ; Carbohydrates - immunology ; Drug Interactions ; GLUCIDE ; Immune System - chemistry ; IMMUNITE ; IMMUNITY ; INMUNIDAD ; LECTINAS ; LECTINE ; LECTINS ; Lectins - chemistry ; Lectins - immunology</subject><ispartof>Veterinary immunology and immunopathology, 1996-12, Vol.55 (1), p.205-223</ispartof><rights>1996</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-6f3c4efe576f2b3bd34d175957880b0fb41fff18135a2496a7446021e9637d4a3</citedby><cites>FETCH-LOGICAL-c476t-6f3c4efe576f2b3bd34d175957880b0fb41fff18135a2496a7446021e9637d4a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9014318$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ni, Y.</creatorcontrib><creatorcontrib>Tizard, I.</creatorcontrib><title>Lectin-carbohydrate interaction in the immune system</title><title>Veterinary immunology and immunopathology</title><addtitle>Vet Immunol Immunopathol</addtitle><description>The immune system consists of various types of cells and molecules that specifically interact with each other to initiate the host defense mechanism. Recent studies have shown that carbohydrates and lectins (carbohydrate-binding proteins) play an essential role in mediating such interactions. Both lectins and carbohydrates are widely distributed in the mammalian tissues as well as in microorganisms. Carbohydrates, due to their chemical nature, can potentially form structures that are more variable than proteins and nucleic acids. Lectins can exist in either soluble or cell-associated form, and although overall structures vary, invariably possess carbohydrate-recognition domains (CRD) with various specificities. The interaction between lectins and carbohydrates have been shown to be involved in such activities as opsonization of microorganisms, phagocytosis, cell adhesion and migration, cell activation and differentiation, and apoptosis. The number of lectins identified in the immune system is increasing at a rapid pace. The development in this area has opened a new aspect in studying the immune system, and at the same time, provided new therapeutic routes for the treatment and prevention of disease.</description><subject>Animals</subject><subject>CARBOHIDRATOS</subject><subject>CARBOHYDRATES</subject><subject>Carbohydrates - chemistry</subject><subject>Carbohydrates - immunology</subject><subject>Drug Interactions</subject><subject>GLUCIDE</subject><subject>Immune System - chemistry</subject><subject>IMMUNITE</subject><subject>IMMUNITY</subject><subject>INMUNIDAD</subject><subject>LECTINAS</subject><subject>LECTINE</subject><subject>LECTINS</subject><subject>Lectins - chemistry</subject><subject>Lectins - immunology</subject><issn>0165-2427</issn><issn>1873-2534</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><recordid>eNqFkElLA0EQhRtRYoz-ASGQk-hhtPflJBLcIOhBPTc9M9WmJTOj3RMh_97OQq5eqor36lXBh9CY4GuCibx5y0UUlFN1aeQVForogh6gIdGKFVQwfoiG-5VjdJLSF8ZYGK0HaGAw4YzoIeIzqPrQFpWLZTdf1dH1MAltD9FlvWvzPOnnWWqaZQuTtEo9NKfoyLtFgrNdH6GPh_v36VMxe318nt7Nioor2RfSs4qDB6GkpyUra8ZrooQRSmtcYl9y4r0nmjDhKDfSKc4lpgSMZKrmjo3Qxfbud-x-lpB624RUwWLhWuiWyRJhpBQ5P0Jiu1jFLqUI3n7H0Li4sgTbNS27oWXXKKyRdkPL0pwb7x4sywbqfWqHJ_vnW9-7zrrPGJJ9mRmFGdUim7dbEzKC3wDRpipAW0EdYoZq6y788_4PYZaAjg</recordid><startdate>19961201</startdate><enddate>19961201</enddate><creator>Ni, Y.</creator><creator>Tizard, I.</creator><general>Elsevier B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>19961201</creationdate><title>Lectin-carbohydrate interaction in the immune system</title><author>Ni, Y. ; Tizard, I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c476t-6f3c4efe576f2b3bd34d175957880b0fb41fff18135a2496a7446021e9637d4a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>CARBOHIDRATOS</topic><topic>CARBOHYDRATES</topic><topic>Carbohydrates - chemistry</topic><topic>Carbohydrates - immunology</topic><topic>Drug Interactions</topic><topic>GLUCIDE</topic><topic>Immune System - chemistry</topic><topic>IMMUNITE</topic><topic>IMMUNITY</topic><topic>INMUNIDAD</topic><topic>LECTINAS</topic><topic>LECTINE</topic><topic>LECTINS</topic><topic>Lectins - chemistry</topic><topic>Lectins - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ni, Y.</creatorcontrib><creatorcontrib>Tizard, I.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Veterinary immunology and immunopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ni, Y.</au><au>Tizard, I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lectin-carbohydrate interaction in the immune system</atitle><jtitle>Veterinary immunology and immunopathology</jtitle><addtitle>Vet Immunol Immunopathol</addtitle><date>1996-12-01</date><risdate>1996</risdate><volume>55</volume><issue>1</issue><spage>205</spage><epage>223</epage><pages>205-223</pages><issn>0165-2427</issn><eissn>1873-2534</eissn><abstract>The immune system consists of various types of cells and molecules that specifically interact with each other to initiate the host defense mechanism. Recent studies have shown that carbohydrates and lectins (carbohydrate-binding proteins) play an essential role in mediating such interactions. Both lectins and carbohydrates are widely distributed in the mammalian tissues as well as in microorganisms. Carbohydrates, due to their chemical nature, can potentially form structures that are more variable than proteins and nucleic acids. Lectins can exist in either soluble or cell-associated form, and although overall structures vary, invariably possess carbohydrate-recognition domains (CRD) with various specificities. The interaction between lectins and carbohydrates have been shown to be involved in such activities as opsonization of microorganisms, phagocytosis, cell adhesion and migration, cell activation and differentiation, and apoptosis. The number of lectins identified in the immune system is increasing at a rapid pace. The development in this area has opened a new aspect in studying the immune system, and at the same time, provided new therapeutic routes for the treatment and prevention of disease.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>9014318</pmid><doi>10.1016/S0165-2427(96)05718-2</doi><tpages>19</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0165-2427 |
ispartof | Veterinary immunology and immunopathology, 1996-12, Vol.55 (1), p.205-223 |
issn | 0165-2427 1873-2534 |
language | eng |
recordid | cdi_proquest_miscellaneous_15966581 |
source | Elsevier:Jisc Collections:Elsevier Read and Publish Agreement 2022-2024:Freedom Collection (Reading list) |
subjects | Animals CARBOHIDRATOS CARBOHYDRATES Carbohydrates - chemistry Carbohydrates - immunology Drug Interactions GLUCIDE Immune System - chemistry IMMUNITE IMMUNITY INMUNIDAD LECTINAS LECTINE LECTINS Lectins - chemistry Lectins - immunology |
title | Lectin-carbohydrate interaction in the immune system |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T15%3A36%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Lectin-carbohydrate%20interaction%20in%20the%20immune%20system&rft.jtitle=Veterinary%20immunology%20and%20immunopathology&rft.au=Ni,%20Y.&rft.date=1996-12-01&rft.volume=55&rft.issue=1&rft.spage=205&rft.epage=223&rft.pages=205-223&rft.issn=0165-2427&rft.eissn=1873-2534&rft_id=info:doi/10.1016/S0165-2427(96)05718-2&rft_dat=%3Cproquest_cross%3E15966581%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c476t-6f3c4efe576f2b3bd34d175957880b0fb41fff18135a2496a7446021e9637d4a3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=15966581&rft_id=info:pmid/9014318&rfr_iscdi=true |