Prediction of Rodent Carcinogenicity Using the DEREK System for 30 Chemicals Currently Being Tested by the National Toxicology Program

DEREK is a knowledge-based expert system for the qualitative prediction of toxicity. The DEREK system has been used to predict the carcinogenicity in rodents of the 30 chemicals in the second National Toxicology Program (NTP) carcinogenicity prediction exercise. Seven of the chemicals were predicted...

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Bibliographic Details
Published in:Environmental health perspectives 1996-10, Vol.104, p.1065-1073
Main Authors: Marchant, Carol A., The DEREK Collaborative Group
Format: Article
Language:English
Subjects:
Ames test
Carcinogenicity
Carcinogens
Chemical hazards
Lesions
Mutagenicity
Rats
Rodents
Salmonella
The Second NIEHS Predictive-Toxicology Evaluation Experiment: 30 Chemical Carcinogenicity Bioassays
Toxicology
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Summary:DEREK is a knowledge-based expert system for the qualitative prediction of toxicity. The DEREK system has been used to predict the carcinogenicity in rodents of the 30 chemicals in the second National Toxicology Program (NTP) carcinogenicity prediction exercise. Seven of the chemicals were predicted to be carcinogens. For 23 chemicals, there was no evidence in the DEREK knowledge base to suggest carcinogenic activity. Supplementary data from a variety of sources have been evaluated by human experts to assess confidence in each DEREK prediction. These sources included standard toxicology reference texts, genotoxicity and subchronic toxicity assay results for each chemical, as well as Salmonella mutagenicity and carcinogenicity data for close structural analogues. This process has led to the proposal of a number of improvements to the DEREK carcinogenicity knowledge base.
ISSN:0091-6765
DOI:10.2307/3433032