Circulating and Ex Vivo Production of Pyrogenic Cytokines and Interleukin-1 Receptor Antagonist in 123 Patients with Fever of Unknown Origin

Circulating and ex vivo production of interleukin (IL)-1β, tumor necrosis factor (TNF)-α, IL-6, and IL-1 receptor antagonist (ra) and the diagnostic utility of these cytokines were studied in 123 patients with fever of unknown origin (FUO). Diagnoses were infections, 28; neoplasms, 14; noninfectious...

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Bibliographic Details
Published in:The Journal of infectious diseases 1997-01, Vol.175 (1), p.191-194
Main Authors: de Kleijn, Elisabeth M. H. A., Drenth, Joost P. H., Pesman, Gerard J., van Druten, Hans, Demacker, Pierre N. M., van der Meer, Jos W. M.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood
Concise Communications
Cytokines
Fever
Fever of unknown origin
General aspects
Human infectious diseases. Experimental studies and models
Infections
Infectious diseases
Interleukins
Medical sciences
Multiple regression
Neoplasia
Phlebotomy
University hospitals
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Summary:Circulating and ex vivo production of interleukin (IL)-1β, tumor necrosis factor (TNF)-α, IL-6, and IL-1 receptor antagonist (ra) and the diagnostic utility of these cytokines were studied in 123 patients with fever of unknown origin (FUO). Diagnoses were infections, 28; neoplasms, 14; noninfectious inflammatory diseases (NIID), 32; miscellaneous diseases, 10; and none made, 39. IL-1β, IL-6, and IL-1ra concentrations were higher in patients with infections, neoplasms, and NIID than in healthy controls. Patients with infections had higher concentrations of TNF-α than controls. The ex vivo production of IL-1β and IL-1ra in all patients with FUQ did not differ from that in controls; however, production of TNF-α was lower in patients with neoplasms and NIID, and IL6 production was lower in patients with neoplasms. Thirty-five patients with fever did not have elevated cytokines. Although some significant differences were found among the diagnostic subgroups, there was wide variation. Thus, measurement of these cytokines does not aid in the diagnosis of FUO.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/175.1.191