Human Immunodeficiency Virus Infection in Tuberculosis Patients

Human immunodeficiency virus (HIV) serologywas performed in non-Asian-bom patients 18–65 years old with newly diagnosed tuberculosis at a county tuberculosis clinic, and demographic and clinical features of HIV-seropositive and HIV-seronegative patients were compared. Sixty of 128 eligible patients...

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Bibliographic Details
Published in:The Journal of infectious diseases 1990-07, Vol.162 (1), p.8-12
Main Authors: Theuer, Charles P., Hopewell, Philip C., Elias, Darlene, Schecter, Gisela F., Rutherford, George W., Chaisson, Richard E.
Format: Article
Language:English
Subjects:
Acquired Immunodeficiency Syndrome - complications
Adult
Age Factors
AIDS
Antibodies
Antitubercular Agents - therapeutic use
Bacteriology
Biological and medical sciences
CD4-Positive T-Lymphocytes
Female
Fundamental and applied biological sciences. Psychology
HIV
HIV infections
HIV Infections - complications
HIV Infections - epidemiology
HIV Seropositivity - complications
HIV Seroprevalence
Humans
Infections
Leukocyte Count
Major Articles
Male
Microbiology
Middle Aged
Mycobacterium tuberculosis
Opportunistic Infections - complications
Predisposing factors
Pulmonary tuberculosis
Risk Factors
Sex Factors
Sputum
Sputum - microbiology
Tuberculin Test
Tuberculosis
Tuberculosis - complications
Tuberculosis - drug therapy
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Summary:Human immunodeficiency virus (HIV) serologywas performed in non-Asian-bom patients 18–65 years old with newly diagnosed tuberculosis at a county tuberculosis clinic, and demographic and clinical features of HIV-seropositive and HIV-seronegative patients were compared. Sixty of 128 eligible patients agreed to participate, of whom 17 (28%) were seropositive. Risk of HIV was associated with homosexual contact, intravenous drug use, or both; however, 4 (24%) of the 17 seropositives denied risk behaviors. Significantly more blacks (48%) than whites (10%) or Latinos (20%) were HIV-seropositive (P < .01). Site of disease, tuberculin reactivity, response to therapy, drug toxicity, and relapse did not differ significantly between groups. HIV-seropositive patients had significantly lower median CD4+ cell counts (326/mm3, range 23–742/mm3 , vs. 929/mm3 , range 145–2962/mm3, P < .0005) and median CD4+:CD8+ ratios (0.50, range 0.14–1.07 vs. 1.54, range 0.35–4.36, P < .0001). HIV infection is associated with clinically typical tuberculosis and HIV screening of tuberculosis patients is recommended in areas where HIV is endemic.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/162.1.8