Comparison of Analytical Methods in the Determination of Two Venlafaxine Fatalities

Two venlafaxine (Effexor)-related deaths are reported with comparison of results from the analysis of specimens using capillary gas chromatography with a nitrogen-phosphorous detector (GC-NPD) and high-performance liquid chromatography (HPLC) using a UV-vis detector. Blood concentrations in Case 1 w...

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Bibliographic Details
Published in:Journal of analytical toxicology 1997-03, Vol.21 (2), p.166-169
Main Authors: Long, Christopher, Crifasi, Joseph, Maginn, Diane, Graham, Michael, Teas, Shaku
Format: Article
Language:English
Subjects:
Adult
Antidepressive Agents, Second-Generation - blood
Antidepressive Agents, Second-Generation - poisoning
Biological and medical sciences
Chromatography, Gas
Chromatography, High Pressure Liquid
Cyclohexanols - blood
Cyclohexanols - poisoning
Desvenlafaxine Succinate
Drug intoxications. Doping
Drug Overdose
Female
Humans
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Venlafaxine Hydrochloride
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Description
Summary:Two venlafaxine (Effexor)-related deaths are reported with comparison of results from the analysis of specimens using capillary gas chromatography with a nitrogen-phosphorous detector (GC-NPD) and high-performance liquid chromatography (HPLC) using a UV-vis detector. Blood concentrations in Case 1 were 7.27 µg/mL venlafaxine and 5.03 µg/mL O-desmethylvenlafaxine, and Case 2 had 89.67 µg/mL venlafaxine with 3.44 µg/mL of the desmethyl metabolite. A comparison of analytical methods and specimen concentration is presented.
ISSN:0146-4760
1945-2403
DOI:10.1093/jat/21.2.166