A mutation in the cAMP signaling pathway affects sexual development of Dictyostelium discoideum

Amoebae of cellular slime molds have two developmental modes, asexual fruiting body formation and sexual macrocyst formation. How developmental choice is made is an interesting subject of wide importance. Light exposure and dry conditions are favorable for asexual development, while conditions of da...

Full description

Saved in:
Bibliographic Details
Published in:Development, growth & differentiation growth & differentiation, 1997-04, Vol.39 (2), p.227-234
Main Authors: Shimizu, Hajime, Morio, Takahiro, Shimizu, Hideki D., Urushihara, Hideko
Format: Article
Language:English
Subjects:
Animals
cAMP
Cell Aggregation
Chemotaxis
Cyclic AMP - physiology
Dictyostelium - genetics
Dictyostelium - growth & development
Dictyostelium discoideum
DNA, Fungal - chemistry
DNA, Protozoan - chemistry
Mutagenesis, Site-Directed
Phenotype
Recombination, Genetic
Restriction Mapping
sexual development
Sexual Maturation - genetics
Sexual Maturation - physiology
Signal Transduction - genetics
Signal Transduction - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c5581-b6595238dd2f8dc2b85e089f1b525aa7e0a2005ea1a99844b73f2c3cae7470173
cites cdi_FETCH-LOGICAL-c5581-b6595238dd2f8dc2b85e089f1b525aa7e0a2005ea1a99844b73f2c3cae7470173
container_end_page 234
container_issue 2
container_start_page 227
container_title Development, growth & differentiation
container_volume 39
creator Shimizu, Hajime
Morio, Takahiro
Shimizu, Hideki D.
Urushihara, Hideko
description Amoebae of cellular slime molds have two developmental modes, asexual fruiting body formation and sexual macrocyst formation. How developmental choice is made is an interesting subject of wide importance. Light exposure and dry conditions are favorable for asexual development, while conditions of darkness and high humidity are so for sexual development. In Dictyostelium discoideum, the latter conditions enhance zygote formation, which determines the fate of surrounding cells for sexual development. Here, a mutant (TMC1) defective in the post‐fusion aggregation of cells during sexual development is described. This mutant is also aggregationless in asexual development, and the level of cyclic adenosine monophosphate (cAMP) receptor is reduced. Correspondingly, a series of existing mutants with defects in cAMP signaling pathways showed the same sexual phenotype as TMC1. These results suggest that molecular mechanisms of development are shared by the two alternative developmental modes.
doi_str_mv 10.1046/j.1440-169X.1997.t01-1-00011.x
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_15996562</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>15996562</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5581-b6595238dd2f8dc2b85e089f1b525aa7e0a2005ea1a99844b73f2c3cae7470173</originalsourceid><addsrcrecordid>eNqVkEtPwzAQhC0EgvL4CUg-9ZbgdeIkviBVLS8JBAeQuFmOs6Gu8iixQ9t_T0qr3jmttDM7O_oIGQMLgcXJzSKEOGYBJPIzBCnT0DMIIGCMAYTrIzI6yMdkNCx5AELyM3Lu3GIwxTHwU3IqgWVRlIyImtC699rbtqG2oX6O1Exe3qizX42ubPNFl9rPV3pDdVmi8Y46XPe6ogX-YNUua2w8bUs6s8ZvWuexsn1NC-tMawvs60tyUurK4dV-XpCP-7v36WPw_PrwNJ08B0aIDII8EVLwKCsKXmaF4XkmkGWyhFxwoXWKTHPGBGrQUmZxnKdRyU1kNKZxyiCNLsh4l7vs2u8enVf10AGrSjfY9k4NEGQiEj4Yb3dG07XOdViqZWdr3W0UMLUlrBZqi1BtEaotYTUQVqD-CKv1EHC9_9TnNRaH8z3SQZ_s9JWtcPPPdDV7mAFEv5FtjYI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>15996562</pqid></control><display><type>article</type><title>A mutation in the cAMP signaling pathway affects sexual development of Dictyostelium discoideum</title><source>Wiley-Blackwell Read &amp; Publish Collection</source><creator>Shimizu, Hajime ; Morio, Takahiro ; Shimizu, Hideki D. ; Urushihara, Hideko</creator><creatorcontrib>Shimizu, Hajime ; Morio, Takahiro ; Shimizu, Hideki D. ; Urushihara, Hideko</creatorcontrib><description>Amoebae of cellular slime molds have two developmental modes, asexual fruiting body formation and sexual macrocyst formation. How developmental choice is made is an interesting subject of wide importance. Light exposure and dry conditions are favorable for asexual development, while conditions of darkness and high humidity are so for sexual development. In Dictyostelium discoideum, the latter conditions enhance zygote formation, which determines the fate of surrounding cells for sexual development. Here, a mutant (TMC1) defective in the post‐fusion aggregation of cells during sexual development is described. This mutant is also aggregationless in asexual development, and the level of cyclic adenosine monophosphate (cAMP) receptor is reduced. Correspondingly, a series of existing mutants with defects in cAMP signaling pathways showed the same sexual phenotype as TMC1. These results suggest that molecular mechanisms of development are shared by the two alternative developmental modes.</description><identifier>ISSN: 0012-1592</identifier><identifier>EISSN: 1440-169X</identifier><identifier>DOI: 10.1046/j.1440-169X.1997.t01-1-00011.x</identifier><identifier>PMID: 9108336</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Pty</publisher><subject>Animals ; cAMP ; Cell Aggregation ; Chemotaxis ; Cyclic AMP - physiology ; Dictyostelium - genetics ; Dictyostelium - growth &amp; development ; Dictyostelium discoideum ; DNA, Fungal - chemistry ; DNA, Protozoan - chemistry ; Mutagenesis, Site-Directed ; Phenotype ; Recombination, Genetic ; Restriction Mapping ; sexual development ; Sexual Maturation - genetics ; Sexual Maturation - physiology ; Signal Transduction - genetics ; Signal Transduction - physiology</subject><ispartof>Development, growth &amp; differentiation, 1997-04, Vol.39 (2), p.227-234</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5581-b6595238dd2f8dc2b85e089f1b525aa7e0a2005ea1a99844b73f2c3cae7470173</citedby><cites>FETCH-LOGICAL-c5581-b6595238dd2f8dc2b85e089f1b525aa7e0a2005ea1a99844b73f2c3cae7470173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9108336$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shimizu, Hajime</creatorcontrib><creatorcontrib>Morio, Takahiro</creatorcontrib><creatorcontrib>Shimizu, Hideki D.</creatorcontrib><creatorcontrib>Urushihara, Hideko</creatorcontrib><title>A mutation in the cAMP signaling pathway affects sexual development of Dictyostelium discoideum</title><title>Development, growth &amp; differentiation</title><addtitle>Dev Growth Differ</addtitle><description>Amoebae of cellular slime molds have two developmental modes, asexual fruiting body formation and sexual macrocyst formation. How developmental choice is made is an interesting subject of wide importance. Light exposure and dry conditions are favorable for asexual development, while conditions of darkness and high humidity are so for sexual development. In Dictyostelium discoideum, the latter conditions enhance zygote formation, which determines the fate of surrounding cells for sexual development. Here, a mutant (TMC1) defective in the post‐fusion aggregation of cells during sexual development is described. This mutant is also aggregationless in asexual development, and the level of cyclic adenosine monophosphate (cAMP) receptor is reduced. Correspondingly, a series of existing mutants with defects in cAMP signaling pathways showed the same sexual phenotype as TMC1. These results suggest that molecular mechanisms of development are shared by the two alternative developmental modes.</description><subject>Animals</subject><subject>cAMP</subject><subject>Cell Aggregation</subject><subject>Chemotaxis</subject><subject>Cyclic AMP - physiology</subject><subject>Dictyostelium - genetics</subject><subject>Dictyostelium - growth &amp; development</subject><subject>Dictyostelium discoideum</subject><subject>DNA, Fungal - chemistry</subject><subject>DNA, Protozoan - chemistry</subject><subject>Mutagenesis, Site-Directed</subject><subject>Phenotype</subject><subject>Recombination, Genetic</subject><subject>Restriction Mapping</subject><subject>sexual development</subject><subject>Sexual Maturation - genetics</subject><subject>Sexual Maturation - physiology</subject><subject>Signal Transduction - genetics</subject><subject>Signal Transduction - physiology</subject><issn>0012-1592</issn><issn>1440-169X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNqVkEtPwzAQhC0EgvL4CUg-9ZbgdeIkviBVLS8JBAeQuFmOs6Gu8iixQ9t_T0qr3jmttDM7O_oIGQMLgcXJzSKEOGYBJPIzBCnT0DMIIGCMAYTrIzI6yMdkNCx5AELyM3Lu3GIwxTHwU3IqgWVRlIyImtC699rbtqG2oX6O1Exe3qizX42ubPNFl9rPV3pDdVmi8Y46XPe6ogX-YNUua2w8bUs6s8ZvWuexsn1NC-tMawvs60tyUurK4dV-XpCP-7v36WPw_PrwNJ08B0aIDII8EVLwKCsKXmaF4XkmkGWyhFxwoXWKTHPGBGrQUmZxnKdRyU1kNKZxyiCNLsh4l7vs2u8enVf10AGrSjfY9k4NEGQiEj4Yb3dG07XOdViqZWdr3W0UMLUlrBZqi1BtEaotYTUQVqD-CKv1EHC9_9TnNRaH8z3SQZ_s9JWtcPPPdDV7mAFEv5FtjYI</recordid><startdate>199704</startdate><enddate>199704</enddate><creator>Shimizu, Hajime</creator><creator>Morio, Takahiro</creator><creator>Shimizu, Hideki D.</creator><creator>Urushihara, Hideko</creator><general>Blackwell Science Pty</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>M7N</scope></search><sort><creationdate>199704</creationdate><title>A mutation in the cAMP signaling pathway affects sexual development of Dictyostelium discoideum</title><author>Shimizu, Hajime ; Morio, Takahiro ; Shimizu, Hideki D. ; Urushihara, Hideko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5581-b6595238dd2f8dc2b85e089f1b525aa7e0a2005ea1a99844b73f2c3cae7470173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>cAMP</topic><topic>Cell Aggregation</topic><topic>Chemotaxis</topic><topic>Cyclic AMP - physiology</topic><topic>Dictyostelium - genetics</topic><topic>Dictyostelium - growth &amp; development</topic><topic>Dictyostelium discoideum</topic><topic>DNA, Fungal - chemistry</topic><topic>DNA, Protozoan - chemistry</topic><topic>Mutagenesis, Site-Directed</topic><topic>Phenotype</topic><topic>Recombination, Genetic</topic><topic>Restriction Mapping</topic><topic>sexual development</topic><topic>Sexual Maturation - genetics</topic><topic>Sexual Maturation - physiology</topic><topic>Signal Transduction - genetics</topic><topic>Signal Transduction - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shimizu, Hajime</creatorcontrib><creatorcontrib>Morio, Takahiro</creatorcontrib><creatorcontrib>Shimizu, Hideki D.</creatorcontrib><creatorcontrib>Urushihara, Hideko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><jtitle>Development, growth &amp; differentiation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shimizu, Hajime</au><au>Morio, Takahiro</au><au>Shimizu, Hideki D.</au><au>Urushihara, Hideko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A mutation in the cAMP signaling pathway affects sexual development of Dictyostelium discoideum</atitle><jtitle>Development, growth &amp; differentiation</jtitle><addtitle>Dev Growth Differ</addtitle><date>1997-04</date><risdate>1997</risdate><volume>39</volume><issue>2</issue><spage>227</spage><epage>234</epage><pages>227-234</pages><issn>0012-1592</issn><eissn>1440-169X</eissn><abstract>Amoebae of cellular slime molds have two developmental modes, asexual fruiting body formation and sexual macrocyst formation. How developmental choice is made is an interesting subject of wide importance. Light exposure and dry conditions are favorable for asexual development, while conditions of darkness and high humidity are so for sexual development. In Dictyostelium discoideum, the latter conditions enhance zygote formation, which determines the fate of surrounding cells for sexual development. Here, a mutant (TMC1) defective in the post‐fusion aggregation of cells during sexual development is described. This mutant is also aggregationless in asexual development, and the level of cyclic adenosine monophosphate (cAMP) receptor is reduced. Correspondingly, a series of existing mutants with defects in cAMP signaling pathways showed the same sexual phenotype as TMC1. These results suggest that molecular mechanisms of development are shared by the two alternative developmental modes.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Pty</pub><pmid>9108336</pmid><doi>10.1046/j.1440-169X.1997.t01-1-00011.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0012-1592
ispartof Development, growth & differentiation, 1997-04, Vol.39 (2), p.227-234
issn 0012-1592
1440-169X
language eng
recordid cdi_proquest_miscellaneous_15996562
source Wiley-Blackwell Read & Publish Collection
subjects Animals
cAMP
Cell Aggregation
Chemotaxis
Cyclic AMP - physiology
Dictyostelium - genetics
Dictyostelium - growth & development
Dictyostelium discoideum
DNA, Fungal - chemistry
DNA, Protozoan - chemistry
Mutagenesis, Site-Directed
Phenotype
Recombination, Genetic
Restriction Mapping
sexual development
Sexual Maturation - genetics
Sexual Maturation - physiology
Signal Transduction - genetics
Signal Transduction - physiology
title A mutation in the cAMP signaling pathway affects sexual development of Dictyostelium discoideum
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T03%3A09%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20mutation%20in%20the%20cAMP%20signaling%20pathway%20affects%20sexual%20development%20of%20Dictyostelium%20discoideum&rft.jtitle=Development,%20growth%20&%20differentiation&rft.au=Shimizu,%20Hajime&rft.date=1997-04&rft.volume=39&rft.issue=2&rft.spage=227&rft.epage=234&rft.pages=227-234&rft.issn=0012-1592&rft.eissn=1440-169X&rft_id=info:doi/10.1046/j.1440-169X.1997.t01-1-00011.x&rft_dat=%3Cproquest_cross%3E15996562%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c5581-b6595238dd2f8dc2b85e089f1b525aa7e0a2005ea1a99844b73f2c3cae7470173%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=15996562&rft_id=info:pmid/9108336&rfr_iscdi=true