In-vitro killing activity of combinations of β-lactam agents with aminoglycosides against penicillin-resistant pneumococci

Streptococcus pneumoniae has developed resistance to almost every antibacterial agent used in clinical practice, including the most active beta-lactams. This has led to the proposed use of drug combinations. The aim of this study was to determine the efficacy of combinations of beta-lactam agents (c...

Full description

Saved in:
Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1997, Vol.39 (1), p.95-98
Main Authors: SCHLEGEL, L, SISSIA, G, FREMAUX, A, GESLIN, P
Format: Article
Language:English
Subjects:
Aminoglycosides
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
beta-Lactams
Biological and medical sciences
Child
Colony Count, Microbial
Drug Synergism
Drug Therapy, Combination - pharmacology
Humans
Kinetics
Medical sciences
Meningitis, Pneumococcal - microbiology
Microbial Sensitivity Tests
Penicillin Resistance
Pharmacology. Drug treatments
Streptococcus pneumoniae
Streptococcus pneumoniae - drug effects
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Streptococcus pneumoniae has developed resistance to almost every antibacterial agent used in clinical practice, including the most active beta-lactams. This has led to the proposed use of drug combinations. The aim of this study was to determine the efficacy of combinations of beta-lactam agents (cefotaxime or imipenem) with aminoglycosides (gentamicin, netilmicin or amikacin) against pneumococci showing high-level resistance to penicillin and streptomycin and/or kanamycin. All tested combinations were bactericidal and synergic despite the weak concentrations of antibiotics used. Our results suggest that combinations of beta-lactam agents with aminoglycosides may be useful for treating infections by penicillin-resistant pneumococci located outside the central nervous system.
ISSN:0305-7453
1460-2091
1460-2091
DOI:10.1093/jac/39.1.95