Galanin receptors: Involvement in feeding, pain, depression and Alzheimer's disease

Galanin, a neuroendocrine peptide with a multitude of functions, binds to and acts on specific G-protein coupled receptors. Only one galanin receptor subtype, GalR1, has been cloned so far, although pharmacological evidence suggests the presence of more than one galanin receptor subtype. These recep...

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Bibliographic Details
Published in:Life Sciences 1997, Vol.60 (18), p.1523-1533
Main Authors: Kask, Kalev, Berthold, Malin, Bartfai, Tamas
Format: Article
Language:English
Subjects:
Alzheimer Disease - physiopathology
Amino Acid Sequence
Animals
Depression - physiopathology
Eating - physiology
G-protein coupled receptors
galanin
Galanin - physiology
Humans
ligand binding site
Mammalia
Models, Molecular
Molecular Sequence Data
mutagenesis
neuropeptide
Pain - physiopathology
receptor subtypes
Receptors, Galanin
Receptors, Gastrointestinal Hormone - physiology
Signal Transduction
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Summary:Galanin, a neuroendocrine peptide with a multitude of functions, binds to and acts on specific G-protein coupled receptors. Only one galanin receptor subtype, GalR1, has been cloned so far, although pharmacological evidence suggests the presence of more than one galanin receptor subtype. These receptors mediate via different G i/G o-proteins the inhibition of adenylyl cyclase, opening of K +-channels and closure of Ca 2+-channels. Galanin inhibits secretion of insulin, acetylcholine, serotonin and noradrenaline, while it stimulates prolactin and growth hormone release. Determination of structural components of galanin receptors required for binding of the peptide ligand as carried out recently will facilitate the screening and design of molecules specifically acting on galaninergic systems with therapeutic potential in Alzheimer's disease, feeding disorders, pain and depression.
ISSN:0024-3205
1879-0631
DOI:10.1016/S0024-3205(96)00624-8