Functional maturation of an antiviral cytotoxic T-cell response

Lymphocytic choriomeningitis virus (LCMV) is known to induce strong, polyclonal cytotoxic T-lymphocyte (CTL) responses. Using a set of variant peptides derived from the major CTL epitope of LCMV, we analyzed the functional fine specificity of the LCMV-specific CTL response. During the primary respon...

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Bibliographic Details
Published in:Journal of virology 1997-08, Vol.71 (8), p.5764-5768
Main Authors: Bachmann, M F, Speiser, DE, Ohashi, P S
Format: Article
Language:English
Subjects:
lymphocytic choriomeningitis virus
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Summary:Lymphocytic choriomeningitis virus (LCMV) is known to induce strong, polyclonal cytotoxic T-lymphocyte (CTL) responses. Using a set of variant peptides derived from the major CTL epitope of LCMV, we analyzed the functional fine specificity of the LCMV-specific CTL response. During the primary response, almost all the tested peptides were recognized. In contrast, the secondary response was purged of all minor cross-reactivities and very few peptides were significantly recognized. This study is the first demonstration of the functional maturation of a T-cell response and has important clinical and biological implications.
ISSN:0022-538X
DOI:10.1128/jvi.71.8.5764-5768.1997