Effects of repeated injections of palytoxin on lymphoid tissues in mice

Sublethal doses of palytoxin were i.p. injected repeatedly to mice, and the effects on lymphoid tissues were examined. The weight and morphology of the thymus were influenced during exposure but had generally recovered after 1 month of withdrawal. The ratio of lymphocytes to total leukocytes in bloo...

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Bibliographic Details
Published in:Toxicon (Oxford) 1997-05, Vol.35 (5), p.679-688
Main Authors: Ito, Emiko, Ohkusu, Misako, Terao, Kiyoshi, Yasumoto, Takeshi
Format: Article
Language:English
Subjects:
Acrylamides - administration & dosage
Acrylamides - toxicity
Animal poisons toxicology. Antivenoms
Animals
B-lymphocytes
Biological and medical sciences
Brachyura
Cnidarian Venoms - administration & dosage
Cnidarian Venoms - toxicity
crabs
demania alcalai
Flow Cytometry
Injections, Intraperitoneal
intraperitoneal injection
isolation
leukocytes
Lymphocyte Count
lymphocytes
Lymphoid Tissue - drug effects
Lymphoid Tissue - pathology
Male
Medical sciences
Mice
Mice, Inbred ICR
Organ Size - drug effects
ratios
spleen
Spleen - drug effects
Spleen - pathology
thymus gland
Thymus Gland - drug effects
Thymus Gland - pathology
toxicity
Toxicology
toxins
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Summary:Sublethal doses of palytoxin were i.p. injected repeatedly to mice, and the effects on lymphoid tissues were examined. The weight and morphology of the thymus were influenced during exposure but had generally recovered after 1 month of withdrawal. The ratio of lymphocytes to total leukocytes in blood was decreased during the injection term, and did not recover to a normal level even after 1 month of withdrawal. The component of B-cells in the lymphocytes was clarified as being responsible for the small number of lymphocytes in the recovery process.
ISSN:0041-0101
1879-3150
DOI:10.1016/S0041-0101(96)00184-5