Humoral immunity induced in the lower respiratory tract by local immunization with a temperature-sensitive mutant of Pseudomonas aeruginosa

The nature of the humoral immune mechanisms involved in the protection induced after local immunization with a temperature-sensitive (ts) mutant of Pseudomonas aeruginosa was investigated. Intranasal immunization induced high levels of anti-P. aeruginosa IgG and IgA in the lower respiratory tract, w...

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Bibliographic Details
Published in:Current microbiology 1991-04, Vol.22 (4), p.265-269
Main Authors: GARCIA, V. E, SORDELLI, D. O, GHERARDI, M. M, HOOKE, A. M
Format: Article
Language:English
Subjects:
Analysis of the immune response. Humoral and cellular immunity
Antibody production
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Immunobiology
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Summary:The nature of the humoral immune mechanisms involved in the protection induced after local immunization with a temperature-sensitive (ts) mutant of Pseudomonas aeruginosa was investigated. Intranasal immunization induced high levels of anti-P. aeruginosa IgG and IgA in the lower respiratory tract, whereas only modest levels of IgG (and no IgA) could be detected in lung lavage fluids from mice immunized by the intraperitoneal (i.p.) route with ts mutant E/9/9. Plasma anti-P. aeruginosa IgG levels after i.n. immunization were lower than those observed after i.p. immunization with similar doses of the ts mutant. The main contribution to the protection induced when mice are immunized intranasally appears to be from IgA in the pulmonary secretions, although other immune mechanisms cannot be discounted.
ISSN:0343-8651
1432-0991
DOI:10.1007/BF02092320