Prevalence of the speA2 and speA3 alleles in Streptococcus pyogenes isolated from TSLS patients in Japan

More than 100 cases have been identified as streptococcal toxic shock-like syndrome (TSLS) in Japan, since the first case was reported in 1993. Of 26 S. pyogenes isolates associated with TSLS, 69% were M-types 1 and 3. This study focused on speA alleles which were carried by all M-type 1 and 3 isola...

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Bibliographic Details
Published in:FEMS microbiology letters 1997-05, Vol.150 (2), p.233-237
Main Authors: Matsumoto, Masakado, Murai, Teiko, Ichiyama, Satoshi, Saito, Makoto, Arakawa, Yoshichika, Ohta, Michio
Format: Article
Language:English
Subjects:
Alleles
Amino Acid Sequence
Bacterial Proteins
Base Sequence
Exotoxins - classification
Exotoxins - genetics
Female
Gene Frequency
Genes, Bacterial
Genotype
Humans
Japan - epidemiology
Male
Membrane Proteins
Molecular Sequence Data
Sequence Alignment
Sequence Homology
Shock, Septic - epidemiology
Shock, Septic - microbiology
speA allele
Streptococcus pyogenes
Streptococcus pyogenes - genetics
Streptococcus pyogenes - isolation & purification
TSLS
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Summary:More than 100 cases have been identified as streptococcal toxic shock-like syndrome (TSLS) in Japan, since the first case was reported in 1993. Of 26 S. pyogenes isolates associated with TSLS, 69% were M-types 1 and 3. This study focused on speA alleles which were carried by all M-type 1 and 3 isolates and isolates of some other M-types, irrespective of sources. We sequenced the nucleotides of the relevant region of the speA allele in all of these isolates. Consistent with other reports, these M-type 1 and 3 isolates carried the speA2 and speA3 alleles, respectively. Our results indicate that these two speA alleles, which were prevalent worldwidely have been disseminating in Japan.
ISSN:0378-1097
1574-6968
DOI:10.1016/S0378-1097(97)00120-1