Nucleotide sequence of the Yersinia pestis gene encoding F1 antigen and the primary structure of the protein. Putative T and B cell epitopes

The plasmid-located gene caf1 encoding the capsular antigen fraction 1 (F1) of Yersinia pestis was cloned and sequenced. The gene codes for a 170 amino acid peptide with a deduced M sub(r) of 17.6 kDa. The signal peptide sequence was highly homologous to the E. coli) consensus signal sequence. The F...

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Bibliographic Details
Published in:FEBS letters 1990-01, Vol.227 (1-2), p.230-232
Main Authors: Galyov, EE, Smirnov, OYu, Karlishev, A V, Volkovoy, KI, Denesyuk, AI, Nazimov, I V, Rubtsov, K S, Abramov, V M, Dalvadyanz, S M, Zav'yalov, V P
Format: Article
Language:English
Subjects:
F1 antigen
genes
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Summary:The plasmid-located gene caf1 encoding the capsular antigen fraction 1 (F1) of Yersinia pestis was cloned and sequenced. The gene codes for a 170 amino acid peptide with a deduced M sub(r) of 17.6 kDa. The signal peptide sequence was highly homologous to the E. coli) consensus signal sequence. The F1 was assumed to have beta -sheet structure for the most part. The region located between amino acids 100 and 150 was suggested to contain putative antigenic determinants and to stimulate T cells.
ISSN:0014-5793