Programme for long-term retention studies of super(14)C-labelled compounds in man using the Lund AMS facility

Organic compounds labelled with super(14)C are routinely and widely used in clinical medicine and biomedical research. There are, however, considerable uncertainties in the current estimates of the absorbed doses to the body from super(14)C-labelled radiopharmaceuticals. In this paper a project is d...

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Published in:Nuclear instruments & methods in physics research. Section B, Beam interactions with materials and atoms Beam interactions with materials and atoms, 1997-01, Vol.123 (1-4), p.245-248
Main Authors: Stenstrom, Kristina, Leide-Svegborn, Sigrid, Erlandsson, Bengt, Hellborg, Ragnar, Skog, Goran, Mattsson, Soren, Nilsson, Lars-Erik, Nosslin, Bertil
Format: Article
Language:English
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Summary:Organic compounds labelled with super(14)C are routinely and widely used in clinical medicine and biomedical research. There are, however, considerable uncertainties in the current estimates of the absorbed doses to the body from super(14)C-labelled radiopharmaceuticals. In this paper a project is described using accelerator mass spectrometry (AMS) to perform investigations of the long-term biokinetics of super(14)C from various super(14)C-labelled pharmaceuticals in man. The use of the AMS technique makes it possible to follow the turnover of the radionuclide administered for extensive periods and also to decrease the activity administered.
ISSN:0168-583X