Relationship of genes encoding Ca super(2+)/calmodulin-dependent protein kinase Gr and calspermin: A gene within a gene

Ca super(2+)/calmodulin-dependent protein kinase enriched in cerebellar granule cells (CaM kinase Gr) is a neuronal calmodulin-dependent protein kinase whose purification and partial cloning from rat brain has been described. A combination of the polymerase chain reaction and cDNA library screening...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1991-01, Vol.88 (13), p.5784-5788
Main Authors: Ohmstede, C-A, Bland, M M, Merrill, B M, Sahyoun, N
Format: Article
Language:English
Subjects:
brain
calcium
calmodulin
cerebellum
genes
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Summary:Ca super(2+)/calmodulin-dependent protein kinase enriched in cerebellar granule cells (CaM kinase Gr) is a neuronal calmodulin-dependent protein kinase whose purification and partial cloning from rat brain has been described. A combination of the polymerase chain reaction and cDNA library screening was used to determine the DNA sequence that encodes most of the remaining polypeptide sequence. The deduced amino acid sequence was confirmed by comparison with the peptide sequence from purified CaM kinase Gr. Analysis of this sequence indicated the presence of potential catalytic, regulatory, and association domains with 42% overall homology to the alpha subunit of another neuronal Ca super(2+)/calmodulin-dependent protein kinase, CaM kinase II.
ISSN:0027-8424