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A study of ethylene glycol exposure and kidney function of aircraft de-icing workers

Ethylene glycol levels were measured in 154 breathing zone air samples and in 117 urine samples of 33 aviation workers exposed to de-icing fluid (basket operators, de-icing truck drivers, leads and coordinators) studied during 42 worker-days over a winter period of 2 months at a Montreal airport. Et...

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Published in:International archives of occupational and environmental health 1997, Vol.69 (4), p.255-265
Main Authors: GERIN, M, PATRICE, S, BEGIN, D, GOLDBERG, M. S, VYSKOCIL, A, ADIB, G, DROLET, D, VIAU, C
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container_title International archives of occupational and environmental health
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PATRICE, S
BEGIN, D
GOLDBERG, M. S
VYSKOCIL, A
ADIB, G
DROLET, D
VIAU, C
description Ethylene glycol levels were measured in 154 breathing zone air samples and in 117 urine samples of 33 aviation workers exposed to de-icing fluid (basket operators, de-icing truck drivers, leads and coordinators) studied during 42 worker-days over a winter period of 2 months at a Montreal airport. Ethylene glycol as vapour did not exceed 22 mg/m3 (mean duration of samples 50 min). Mist was quantified at higher levels in 3 samples concerning 1 coordinator and 2 basket operators (76-190 mg/m3, 45-118 min). In 16 cases workers' post-shift or next-morning urine contained quantities of ethylene glycol exceeding 5 mmol/mol creatinine (up to 129 mmol/mol creatinine), with most of these instances occurring in basket operators and coordinators, some of whom did not wear paper masks and/or were accidentally sprayed with de-icing fluid. Diethylene glycol was also found in a few air and urinary samples at levels around one tenth those of ethylene glycol. Urinary concentrations of albumin, beta-N-acetyl-glucosaminidase, beta-2-microglobulin and retinol-binding protein were measured and compared over various periods, according to subgroups based on exposure level and according to the frequency of extreme values. These analyses did not demonstrate acute or chronic kidney damage that could be attributed to working in the presence of ethylene glycol. In conclusion, this study does not suggest important health effects of exposure to de-icing fluid in this group of workers. Potential for overexposure exists, however, in certain work situations, and recommendations on preventive measures are given. In addition, these results suggest that other routes of absorption than inhalation, such as the percutaneous route, may be important and that urinary ethylene glycol may be a useful indicator of exposure to ethylene glycol.
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Toxic occupational diseases</subject><subject>Ethylene Glycol</subject><subject>Ethylene Glycols - adverse effects</subject><subject>Ethylene Glycols - urine</subject><subject>Humans</subject><subject>Ice</subject><subject>Kidney - drug effects</subject><subject>Kidney - physiopathology</subject><subject>Kidney Diseases - chemically induced</subject><subject>Kidney Diseases - physiopathology</subject><subject>Kidney Diseases - urine</subject><subject>Kidney Function Tests</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Occupational Diseases - chemically induced</subject><subject>Occupational Diseases - physiopathology</subject><subject>Occupational Diseases - urine</subject><subject>Occupational Exposure - adverse effects</subject><subject>Retinol-Binding Proteins - urine</subject><subject>Toxicology</subject><subject>Various organic compounds</subject><issn>0340-0131</issn><issn>1432-1246</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNpVkDtPwzAUhS0EKqUwMiJ5QGyB69hx3LGqeEmVWMocOX4U09QudiLIvyeoUSWmO5zvHul8CF0TuCcA5UMCYDkAFEBYcYKmhNE8Iznjp2gKlEEGhJJzdJHSJwApeUknaDInVAw_U7Re4NR2usfBYtN-9I3xBm-aXoUGm599SF00WHqNt05702PbedW64P946aKK0rZYm8wp5zf4O8StiekSnVnZJHM13hl6f3pcL1-y1dvz63KxyhRlos1KZYWiUJS8tlJwzbnQjDJbsKKslarZvNDEQK6GnZJpqgshcjm3gkuhQHA6Q3eH3n0MX51JbbVzSZmmkd6ELlWEA2M5FQOYHUAVQ0rR2Gof3U7GviJQ_Vms_lkc-JuxuKt3Rh_pUduQ3465TEo2NkqvXDpiOc_psIv-AvJ2eNg</recordid><startdate>1997</startdate><enddate>1997</enddate><creator>GERIN, M</creator><creator>PATRICE, S</creator><creator>BEGIN, D</creator><creator>GOLDBERG, M. 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Toxic occupational diseases</topic><topic>Ethylene Glycol</topic><topic>Ethylene Glycols - adverse effects</topic><topic>Ethylene Glycols - urine</topic><topic>Humans</topic><topic>Ice</topic><topic>Kidney - drug effects</topic><topic>Kidney - physiopathology</topic><topic>Kidney Diseases - chemically induced</topic><topic>Kidney Diseases - physiopathology</topic><topic>Kidney Diseases - urine</topic><topic>Kidney Function Tests</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Occupational Diseases - chemically induced</topic><topic>Occupational Diseases - physiopathology</topic><topic>Occupational Diseases - urine</topic><topic>Occupational Exposure - adverse effects</topic><topic>Retinol-Binding Proteins - urine</topic><topic>Toxicology</topic><topic>Various organic compounds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GERIN, M</creatorcontrib><creatorcontrib>PATRICE, S</creatorcontrib><creatorcontrib>BEGIN, D</creatorcontrib><creatorcontrib>GOLDBERG, M. 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S</au><au>VYSKOCIL, A</au><au>ADIB, G</au><au>DROLET, D</au><au>VIAU, C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A study of ethylene glycol exposure and kidney function of aircraft de-icing workers</atitle><jtitle>International archives of occupational and environmental health</jtitle><addtitle>Int Arch Occup Environ Health</addtitle><date>1997</date><risdate>1997</risdate><volume>69</volume><issue>4</issue><spage>255</spage><epage>265</epage><pages>255-265</pages><issn>0340-0131</issn><eissn>1432-1246</eissn><coden>IAEHDW</coden><abstract>Ethylene glycol levels were measured in 154 breathing zone air samples and in 117 urine samples of 33 aviation workers exposed to de-icing fluid (basket operators, de-icing truck drivers, leads and coordinators) studied during 42 worker-days over a winter period of 2 months at a Montreal airport. Ethylene glycol as vapour did not exceed 22 mg/m3 (mean duration of samples 50 min). Mist was quantified at higher levels in 3 samples concerning 1 coordinator and 2 basket operators (76-190 mg/m3, 45-118 min). In 16 cases workers' post-shift or next-morning urine contained quantities of ethylene glycol exceeding 5 mmol/mol creatinine (up to 129 mmol/mol creatinine), with most of these instances occurring in basket operators and coordinators, some of whom did not wear paper masks and/or were accidentally sprayed with de-icing fluid. Diethylene glycol was also found in a few air and urinary samples at levels around one tenth those of ethylene glycol. Urinary concentrations of albumin, beta-N-acetyl-glucosaminidase, beta-2-microglobulin and retinol-binding protein were measured and compared over various periods, according to subgroups based on exposure level and according to the frequency of extreme values. These analyses did not demonstrate acute or chronic kidney damage that could be attributed to working in the presence of ethylene glycol. In conclusion, this study does not suggest important health effects of exposure to de-icing fluid in this group of workers. Potential for overexposure exists, however, in certain work situations, and recommendations on preventive measures are given. In addition, these results suggest that other routes of absorption than inhalation, such as the percutaneous route, may be important and that urinary ethylene glycol may be a useful indicator of exposure to ethylene glycol.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>9138000</pmid><doi>10.1007/s004200050145</doi><tpages>11</tpages></addata></record>
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1432-1246
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subjects Acetylglucosaminidase - urine
Aircraft
Albuminuria - metabolism
beta 2-Microglobulin - urine
Biological and medical sciences
Chemical and industrial products toxicology. Toxic occupational diseases
Ethylene Glycol
Ethylene Glycols - adverse effects
Ethylene Glycols - urine
Humans
Ice
Kidney - drug effects
Kidney - physiopathology
Kidney Diseases - chemically induced
Kidney Diseases - physiopathology
Kidney Diseases - urine
Kidney Function Tests
Male
Medical sciences
Occupational Diseases - chemically induced
Occupational Diseases - physiopathology
Occupational Diseases - urine
Occupational Exposure - adverse effects
Retinol-Binding Proteins - urine
Toxicology
Various organic compounds
title A study of ethylene glycol exposure and kidney function of aircraft de-icing workers
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