Lymphokine secretion and cytotoxic activity of human CD4 super(+) T-cell clones against Bordetella pertussis

Human CD4 super(+) T-cell clones specific for pertussis toxin and other Bordetella pertussis) antigens have been tested for their cytotoxic activity, lymphokine production, and capacity to induce immunoglobulin synthesis. All of the T-cell clones produced mostly interleukin-2 and gamma interferon an...

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Bibliographic Details
Published in:Infection and immunity 1991-01, Vol.59 (10), p.3768-3773
Main Authors: Peppoloni, S, Nencioni, L, Di Tommaso, A, Tagliabue, A, Parronchi, P, Romagnani, S, Rappuoli, R, de Magistris, MT
Format: Article
Language:English
Subjects:
Bordetella pertussis
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Summary:Human CD4 super(+) T-cell clones specific for pertussis toxin and other Bordetella pertussis) antigens have been tested for their cytotoxic activity, lymphokine production, and capacity to induce immunoglobulin synthesis. All of the T-cell clones produced mostly interleukin-2 and gamma interferon and assisted allogeneic B cells in the production of immunoglobulins M and G but not immunoglobulin E. The potential in vivo role of the cytotoxic activity of these clones is discussed.
ISSN:0019-9567