Rigidified macrocyclic lanthanide chelates for magnetic resonance imaging

New macrocyclic lanthanide chelates that are potential contrast agents for magnetic resonance imaging have been synthesized. The ligands are derived from 1,4,7,10-tetraazacyclododecane-N,NN″,N″′-tetraacetic acid (DOTA) and feature one or two substituting groups directly grafted onto the tetraaza rin...

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Bibliographic Details
Published in:Journal of alloys and compounds 1997-03, Vol.249 (1-2), p.173-177
Main Authors: Jacques, Vincent, Gilsoul, Dominique, Comblin, Vinciane, Desreux, Jean F.
Format: Article
Language:English
Subjects:
Lanthanides
Macrocyclic chelates
NMR spectroscopy
Solution structure
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Summary:New macrocyclic lanthanide chelates that are potential contrast agents for magnetic resonance imaging have been synthesized. The ligands are derived from 1,4,7,10-tetraazacyclododecane-N,NN″,N″′-tetraacetic acid (DOTA) and feature one or two substituting groups directly grafted onto the tetraaza ring. The rigidity of the chelates as seen in the NMR spectra of paramagnetic species depends directly on the steric preferences of the macrocyclic unit. The solution structures of the rigid species are deduced from a quantitative analysis of the paramagnetic shifts.
ISSN:0925-8388
1873-4669
DOI:10.1016/S0925-8388(96)02529-7