Rigidified macrocyclic lanthanide chelates for magnetic resonance imaging

New macrocyclic lanthanide chelates that are potential contrast agents for magnetic resonance imaging have been synthesized. The ligands are derived from 1,4,7,10-tetraazacyclododecane-N,NN″,N″′-tetraacetic acid (DOTA) and feature one or two substituting groups directly grafted onto the tetraaza rin...

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Published in:Journal of alloys and compounds 1997-03, Vol.249 (1-2), p.173-177
Main Authors: Jacques, Vincent, Gilsoul, Dominique, Comblin, Vinciane, Desreux, Jean F.
Format: Article
Language:English
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Lanthanides
Macrocyclic chelates
NMR spectroscopy
Solution structure
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description New macrocyclic lanthanide chelates that are potential contrast agents for magnetic resonance imaging have been synthesized. The ligands are derived from 1,4,7,10-tetraazacyclododecane-N,NN″,N″′-tetraacetic acid (DOTA) and feature one or two substituting groups directly grafted onto the tetraaza ring. The rigidity of the chelates as seen in the NMR spectra of paramagnetic species depends directly on the steric preferences of the macrocyclic unit. The solution structures of the rigid species are deduced from a quantitative analysis of the paramagnetic shifts.
doi_str_mv 10.1016/S0925-8388(96)02529-7
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subjects Lanthanides
Macrocyclic chelates
NMR spectroscopy
Solution structure
title Rigidified macrocyclic lanthanide chelates for magnetic resonance imaging
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