Rapid analysis of malathion in blood using head space-solid phase microextraction and selected ion monitoring

A simple and rapid method for analysis of malathion in blood was developed using head space-solid phase microextraction (HS-SPME) and gas chromatography mass spectrometry/ electron impact ionization-selected ion monitoring (GC-MS/EI-SIM). A vial containing a blood sample, ammonium sulphate, sulphuri...

Full description

Saved in:
Bibliographic Details
Published in:Forensic science international 1997-08, Vol.88 (2), p.125-131
Main Authors: Namera, Akira, Yashiki, Mikio, Nagasawa, Nobuyuki, Iwasaki, Yasumasa, Kojima, Tohru
Format: Article
Language:English
Subjects:
Adult
Ammonium
Ammonium sulfate
Biological and medical sciences
Blood
Body Fluids - chemistry
Calibration
Electron impact
Fenitrothion
Forensic Medicine - methods
Gas chromatography
Gas chromatography-mass spectrometry
Gas Chromatography-Mass Spectrometry - methods
Head space
Headspace
Humans
Insecticides - blood
Ionization
Malathion
Malathion - blood
Malathion - poisoning
Male
Mass spectrometry
Mass spectroscopy
Medical sciences
Middle Aged
Monitoring
Pesticides, fertilizers and other agrochemicals toxicology
Solid phase methods
Solid phase microextraction
Solid phases
Sulfuric acid
Toxicology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A simple and rapid method for analysis of malathion in blood was developed using head space-solid phase microextraction (HS-SPME) and gas chromatography mass spectrometry/ electron impact ionization-selected ion monitoring (GC-MS/EI-SIM). A vial containing a blood sample, ammonium sulphate, sulphuric acid and fenitrothion as an internal standard, was heated at 90 °C for 15 min. The extraction fiber of the SPME was exposed for 5 min in the head space of the vial. The compounds absorbed on the fiber were detached by exposing the fibre in the injection port of GC-MS. A straight calibration curve was obtained between malathion concentrations of 2.5 to 50.0 μg g −1 in blood. No interfering substances were found, and the time for analysis was 40 min for one sample.
ISSN:0379-0738
1872-6283
DOI:10.1016/S0379-0738(97)00062-5