Synthesis and bioactivity of N super( omega )-hydroxyarginine: A possible intermediate in the biosynthesis of nitric oxide from arginine

Nitric oxide (NO) has recently been found to be an endogenous molecule of extreme biological importance in mammalian cells. Though a significant amount of research has been conducted in determining the physiological role of NO, little work has been performed in elucidating the mechanistic pathway of...

Full description

Saved in:
Bibliographic Details
Published in:Journal of medicinal chemistry 1991-01, Vol.34 (5), p.1746-1748
Main Authors: Wallace, G C, Fukuto, J M
Format: Article
Language:English
Subjects:
nitric oxide
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page 1748
container_issue 5
container_start_page 1746
container_title Journal of medicinal chemistry
container_volume 34
creator Wallace, G C
Fukuto, J M
description Nitric oxide (NO) has recently been found to be an endogenous molecule of extreme biological importance in mammalian cells. Though a significant amount of research has been conducted in determining the physiological role of NO, little work has been performed in elucidating the mechanistic pathway of NO formation. One pathway involves initial N super( omega )-hydroxylation of arginine to give N super( omega )-hydroxyl-L-arginine (NOHA) followed by a series of reactions to generate NO. Herein, we describe the synthesis of NOHA and report our preliminary findings regarding its biological activity.
format article
fullrecord <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_miscellaneous_16055062</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>16055062</sourcerecordid><originalsourceid>FETCH-proquest_miscellaneous_160550623</originalsourceid><addsrcrecordid>eNqNzz0KwkAQBeAtFPy9w1SiRWDdoIWdiGJlo72syURHkp24sxFzA49tBLW2Gh48vse0VFdrYyIzN3FH9USuWut4auKueu5rFy4oJGBdCidimwS6U6iBM9iBVCX6MXCBZwuT6FKnnh-19Wdy5HABSyhZhE45ArmAvsCUbHgHaNi3J7-BBnQUPCXAD0oRMs8FfKmBamc2Fxx-bl-NNuvDahuVnm8VSjgWJAnmuXXIlRyncz2b6eahv4svkUdWjw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16055062</pqid></control><display><type>article</type><title>Synthesis and bioactivity of N super( omega )-hydroxyarginine: A possible intermediate in the biosynthesis of nitric oxide from arginine</title><source>ACS CRKN Legacy Archives</source><creator>Wallace, G C ; Fukuto, J M</creator><creatorcontrib>Wallace, G C ; Fukuto, J M</creatorcontrib><description>Nitric oxide (NO) has recently been found to be an endogenous molecule of extreme biological importance in mammalian cells. Though a significant amount of research has been conducted in determining the physiological role of NO, little work has been performed in elucidating the mechanistic pathway of NO formation. One pathway involves initial N super( omega )-hydroxylation of arginine to give N super( omega )-hydroxyl-L-arginine (NOHA) followed by a series of reactions to generate NO. Herein, we describe the synthesis of NOHA and report our preliminary findings regarding its biological activity.</description><identifier>ISSN: 0022-2623</identifier><language>eng</language><subject>nitric oxide</subject><ispartof>Journal of medicinal chemistry, 1991-01, Vol.34 (5), p.1746-1748</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>Wallace, G C</creatorcontrib><creatorcontrib>Fukuto, J M</creatorcontrib><title>Synthesis and bioactivity of N super( omega )-hydroxyarginine: A possible intermediate in the biosynthesis of nitric oxide from arginine</title><title>Journal of medicinal chemistry</title><description>Nitric oxide (NO) has recently been found to be an endogenous molecule of extreme biological importance in mammalian cells. Though a significant amount of research has been conducted in determining the physiological role of NO, little work has been performed in elucidating the mechanistic pathway of NO formation. One pathway involves initial N super( omega )-hydroxylation of arginine to give N super( omega )-hydroxyl-L-arginine (NOHA) followed by a series of reactions to generate NO. Herein, we describe the synthesis of NOHA and report our preliminary findings regarding its biological activity.</description><subject>nitric oxide</subject><issn>0022-2623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><recordid>eNqNzz0KwkAQBeAtFPy9w1SiRWDdoIWdiGJlo72syURHkp24sxFzA49tBLW2Gh48vse0VFdrYyIzN3FH9USuWut4auKueu5rFy4oJGBdCidimwS6U6iBM9iBVCX6MXCBZwuT6FKnnh-19Wdy5HABSyhZhE45ArmAvsCUbHgHaNi3J7-BBnQUPCXAD0oRMs8FfKmBamc2Fxx-bl-NNuvDahuVnm8VSjgWJAnmuXXIlRyncz2b6eahv4svkUdWjw</recordid><startdate>19910101</startdate><enddate>19910101</enddate><creator>Wallace, G C</creator><creator>Fukuto, J M</creator><scope>7QL</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M81</scope><scope>P64</scope></search><sort><creationdate>19910101</creationdate><title>Synthesis and bioactivity of N super( omega )-hydroxyarginine: A possible intermediate in the biosynthesis of nitric oxide from arginine</title><author>Wallace, G C ; Fukuto, J M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_miscellaneous_160550623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>nitric oxide</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wallace, G C</creatorcontrib><creatorcontrib>Fukuto, J M</creatorcontrib><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 3</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wallace, G C</au><au>Fukuto, J M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and bioactivity of N super( omega )-hydroxyarginine: A possible intermediate in the biosynthesis of nitric oxide from arginine</atitle><jtitle>Journal of medicinal chemistry</jtitle><date>1991-01-01</date><risdate>1991</risdate><volume>34</volume><issue>5</issue><spage>1746</spage><epage>1748</epage><pages>1746-1748</pages><issn>0022-2623</issn><abstract>Nitric oxide (NO) has recently been found to be an endogenous molecule of extreme biological importance in mammalian cells. Though a significant amount of research has been conducted in determining the physiological role of NO, little work has been performed in elucidating the mechanistic pathway of NO formation. One pathway involves initial N super( omega )-hydroxylation of arginine to give N super( omega )-hydroxyl-L-arginine (NOHA) followed by a series of reactions to generate NO. Herein, we describe the synthesis of NOHA and report our preliminary findings regarding its biological activity.</abstract></addata></record>
fulltext fulltext
identifier ISSN: 0022-2623
ispartof Journal of medicinal chemistry, 1991-01, Vol.34 (5), p.1746-1748
issn 0022-2623
language eng
recordid cdi_proquest_miscellaneous_16055062
source ACS CRKN Legacy Archives
subjects nitric oxide
title Synthesis and bioactivity of N super( omega )-hydroxyarginine: A possible intermediate in the biosynthesis of nitric oxide from arginine
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T10%3A54%3A17IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Synthesis%20and%20bioactivity%20of%20N%20super(%20omega%20)-hydroxyarginine:%20A%20possible%20intermediate%20in%20the%20biosynthesis%20of%20nitric%20oxide%20from%20arginine&rft.jtitle=Journal%20of%20medicinal%20chemistry&rft.au=Wallace,%20G%20C&rft.date=1991-01-01&rft.volume=34&rft.issue=5&rft.spage=1746&rft.epage=1748&rft.pages=1746-1748&rft.issn=0022-2623&rft_id=info:doi/&rft_dat=%3Cproquest%3E16055062%3C/proquest%3E%3Cgrp_id%3Ecdi_FETCH-proquest_miscellaneous_160550623%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=16055062&rft_id=info:pmid/&rfr_iscdi=true