Role of ion channels in lymphocytes

Ion channels, and ion fluxes in general, appear to regulate a wide variety of processes important to lymphocyte function in normal and disease states. These include resting ionic homeostasis and the more complex signaling events involved in activation, proliferation, cytotoxic function, and volume r...

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Bibliographic Details
Published in:Journal of clinical immunology 1991-09, Vol.11 (5), p.225-238
Main Authors: PREMACK, B. A, GARDNER, P
Format: Article
Language:English
Subjects:
Animals
B-Lymphocytes - physiology
Biological and medical sciences
Cell Differentiation
Cell Division
Electrophysiology
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Immunobiology
Ion Channels - physiology
Ions
Lymphocyte Activation - physiology
Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation
T-Lymphocytes - physiology
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Summary:Ion channels, and ion fluxes in general, appear to regulate a wide variety of processes important to lymphocyte function in normal and disease states. These include resting ionic homeostasis and the more complex signaling events involved in activation, proliferation, cytotoxic function, and volume regulation. The wider application of patch-clamp and microfluorimetry techniques to lymphocytes has helped to clarify some issues and raised many more. It seems likely that rapid progress will be made in our understanding of these areas through a combination of immunological, biochemical, and electrophysiological approaches.
ISSN:0271-9142
1573-2592
DOI:10.1007/BF00918180