Mechanism for regulating cell surface distribution of Na super(+), K super(+)-ATPase in polarized epithelial cells

Restriction of sodium, potassium adenosine triphosphatase (Na super(+), K super(+)-ATPase) to either the apical or basal-lateral membrane domain of polarized epithelial cells is fundamental to vectorial ion and solute transport in many tissues and organs. A restricted membrane distribution of Na sup...

Full description

Saved in:
Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1991-01, Vol.254 (5033), p.847-850
Main Authors: Hammerton, R W, Krzeminski, KA, Mays, R W, Ryan, T A, Wollner, DA, Nelson, W J
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Restriction of sodium, potassium adenosine triphosphatase (Na super(+), K super(+)-ATPase) to either the apical or basal-lateral membrane domain of polarized epithelial cells is fundamental to vectorial ion and solute transport in many tissues and organs. A restricted membrane distribution of Na super(+), K super(+)-ATPase in Madin-Darby canine kidney (MDCK) epithelial cells was found experimentally to be generated by preferential retention of active enzyme in the basal-lateral membrane domain and selective inactivation and loss from the apical membrane domain, rather than by vectorial targeting of newly synthesized protein from the Golgi complex to the basal-lateral membrane domain.
ISSN:0036-8075