Chromosomal changes: radiation sensitive sites on chromosome 2 and their role in radiation myeloid leukaemogenesis in the mouse

The involvement of genomic aberrations in oncogenic processes was hypothesised in the very early years of cancer research. In recent years the application of modern methods of cell and molecular genetics has provided us with unequivocal evidence of this and, in some cases, information on the specifi...

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Bibliographic Details
Published in:Radiation and environmental biophysics 1991, Vol.30 (3), p.177-179
Main Authors: Cox, R, Breckon, G, Silver, A R, Masson, W K, George, A M
Format: Article
Language:English
Subjects:
Animals
Chromosome Aberrations
Chromosomes - radiation effects
Leukemia, Myeloid - genetics
Leukemia, Radiation-Induced - genetics
Mice
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Summary:The involvement of genomic aberrations in oncogenic processes was hypothesised in the very early years of cancer research. In recent years the application of modern methods of cell and molecular genetics has provided us with unequivocal evidence of this and, in some cases, information on the specificity of chromosomal change in neoplasia, on the genes that are consequently modified or lost and on the biochemical sequelae of those changes. Evidence has also accumulated in support of the concept that neoplasia develops through a complex series of clonal genetic and epigenetic changes, some of which involve gross chromosomal change. There is much strong evidence on the involvement of specific chromosomal change in the initiation of murine acute myeloid leukaemia (AML) by radiation.
ISSN:0301-634X
1432-2099
DOI:10.1007/BF01226613