secreted effector protein of Salmonella dublin is translocated into eukaryotic cells and mediates inflammation and fluid secretion in infected ileal mucosa

Enteritis induced by non‐typhoid pathogenic Salmonella is characterized by fluid secretion and inflammatory responses in the infected ileum. The inflammatory response provoked by Salmonella initially consists largely of a neutrophil (PMN) migration into the intestinal mucosa and the gut lumen. The i...

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Bibliographic Details
Published in:Molecular microbiology 1997-09, Vol.25 (5), p.903-912
Main Authors: Galyov, E.E, Wood, M.W, Rosqvist, R, Mullan, P.B, Watson, P.R, Hedges, S, Wallis, T.S
Format: Article
Language:English
Subjects:
Amino Acid Sequence
amino acid sequences
Animals
bacterial proteins
Bacterial Proteins - analysis
Bacterial Proteins - genetics
Bacterial Proteins - physiology
Biological Transport
Body Fluids - metabolism
Cattle
cell invasion
Cloning, Molecular
comparisons
enteritis
Epithelial Cells - microbiology
genbank/u90203
Gene Expression - genetics
Gene Expression - physiology
Genes, Bacterial
HeLa Cells
Humans
Ileitis - microbiology
ileum
inflammation
intestinal mucosa
Intestinal Mucosa - metabolism
Male
Membrane Proteins
Molecular Sequence Data
movement
Mutagenesis
neutrophils
Salmonella - chemistry
Salmonella dublin
Salmonella enterica subsp. enterica serovar Dublin
secretion
sequence alignment
Sequence Homology, Amino Acid
Serine Endopeptidases - metabolism
signalling pathways
sopb gene
sopb protein
structural genes
Translocation, Genetic
virulence
Citations: Items that cite this one
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Description
Summary:Enteritis induced by non‐typhoid pathogenic Salmonella is characterized by fluid secretion and inflammatory responses in the infected ileum. The inflammatory response provoked by Salmonella initially consists largely of a neutrophil (PMN) migration into the intestinal mucosa and the gut lumen. The interactions between Salmonella and intestinal epithelial cells are known to play an essential role in inducing the inflammatory response. Upon interaction with epithelial cells salmonellae are able to elicit transepithelial signalling to neutrophils. This signalling is recognized as a key virulence feature underlying Salmonella‐induced enteritis. However, the nature and mechanism of such signalling has not been clarified to date. Here, we characterize SopB, a novel secreted effector protein of Salmonella dublin, and present data implying that SopB is translocated into eukaryotic cells via a sip‐dependent pathway to promote fluid secretion and inflammatory responses in the infected ileum.
ISSN:0950-382X
1365-2958
DOI:10.1111/j.1365-2958.1997.mmi525.x