Ceftibuten versus cefaclor for the treatment of bronchitis

• Published in: Journal of antimicrobial chemotherapy 1991-10, Vol.28 (4), p.577-580
• Main Authors: Chirurgi, Valerie A., Edelstein, Howard, Oster, Sharon E., Karp, Richard, Cassano, Karen B., Aiken, Stephanie, Krumpe, Peter, McCabe, Robert E.
• Format: Article
• Language: English
• Subjects: Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Bacteria - drug effects; Biological and medical sciences; Bronchitis - drug therapy; Bronchitis - microbiology; Cefaclor - administration & dosage; Cefaclor - therapeutic use; Ceftibuten; Cephalosporins - adverse effects; Cephalosporins - therapeutic use; Female; Humans; Male; Medical sciences; Microbial Sensitivity Tests; Moraxella catarrhalis; Neisseria gonorrhoeae; Neisseria meningitidis; Pharmacology. Drug treatments
• ISSN: 0305-7453; 1460-2091
• DOI: 10.1093/jac/28.4.577

Ceftibuten is an oral third generation cephalosporin with potent antimicrobial activity against Enterobacteriaceae, β-lactamase positive Haemophilia influenzae, Moraxella catarrhalis, Neisseria meningitidis, Neisseria gonorrheae, penicillin-susceptible pneumococci, and β-hemolytic streptococci. To study the efficacy and safety of ceftibuten for treatment of bronchitis, 58 patients were randomized to therapy with either ceftibuten 400 mg once a day or cefaclor 250 mg every 8 h at a ratio of two to one. Of 45 clinically evaluable patients, 28 (87·5%) of the 32 ceftibuten patients and 12 (92·3%) of the 13 cefaclor patients were clinically improved or cured. Of 33 microbiologically evaluable patients, 21 (87·5%) of the 24 ceftibuten patients and eight (80%) of the ten cefaclor patients were cured. Of 56 patients evaluable for adverse effects, three (7·9%) of the 38 ceftibuten patients and one (5·6%) of the 18 cefaclor patients had adverse reactions. In this small study, once-daily ceftibuten appeared as safe and as effective as cefaclor for the treatment of bronchitis.