Butylated hydroxytoluene exposure is necessary to induce lung tumors in BALB mice treated with 3-methylcholanthrene

Chronic butylated hydroxytoluene (BHT) treatment after a single administration of a carcinogen increases lung tumor multiplicity in some inbred strains of mice. We report that BALB/cOla and BALB/cByJ mice given a low dose (10 microg/g of body weight) of 3-methylcholanthrene (MCA) develop no lung tum...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1997-07, Vol.57 (14), p.2832-2834
Main Authors: MALKINSON, A. M, KOSKI, K. M, EVANS, W. A, FESTING, M. F. W
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Butylated Hydroxytoluene - toxicity
Carcinogenesis, carcinogens and anticarcinogens
Chemical agents
Female
Lung Neoplasms - chemically induced
Medical sciences
Methylcholanthrene
Mice
Mice, Inbred BALB C
Tumors
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Summary:Chronic butylated hydroxytoluene (BHT) treatment after a single administration of a carcinogen increases lung tumor multiplicity in some inbred strains of mice. We report that BALB/cOla and BALB/cByJ mice given a low dose (10 microg/g of body weight) of 3-methylcholanthrene (MCA) develop no lung tumors unless this is followed by chronic BHT exposure. Slightly higher MCA doses (15 and 25 microg/g) induce low lung tumor multiplicities (0.6 and 1.9 tumors/mouse, respectively) that are increased 12-26-fold by chronic BHT administration. This low-dose MCA/BHT model in BALB mice will facilitate the identification of genes regulating susceptibility to lung tumor promotion and pulmonary chemopreventative agents that act at a postinitiation site.
ISSN:0008-5472
1538-7445