Effects of BDE-209 and its mixtures with BDE-47 and BDE-99 on multiple biomarkers in Carassius auratus

Highlights • Biomarkers including AChE, EROD, GST, SOD and CAT were used. • The toxicity order of PBDEs was proposed via the integrated biomarker response. • The mixtures showed more negative biological effects than BDE-209 alone.

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Bibliographic Details
Published in:Environmental toxicology and pharmacology 2014-09, Vol.38 (2), p.554-561
Main Authors: Xie, Zhengxin, Lu, Guanghua, Qi, Pengde
Format: Article
Language:English
Subjects:
Acetylcholinesterase - metabolism
Animals
BDE-209
Biomarker
Biomarkers - metabolism
Brain - drug effects
Brain - enzymology
Carassius auratus
Catalase - metabolism
Cytochrome P-450 CYP1A1 - metabolism
Dose-Response Relationship, Drug
Emergency
Fish Proteins - metabolism
Gene Expression Regulation, Enzymologic - drug effects
Goldfish - metabolism
Halogenated Diphenyl Ethers - toxicity
IBR
Liver - drug effects
Liver - enzymology
Superoxide Dismutase - metabolism
Water Pollutants, Chemical - toxicity
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Description
Summary:Highlights • Biomarkers including AChE, EROD, GST, SOD and CAT were used. • The toxicity order of PBDEs was proposed via the integrated biomarker response. • The mixtures showed more negative biological effects than BDE-209 alone.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2014.08.008