Sorafenib regulating ERK signals pathway in gastric cancer cell

Highlights • Migration, invasion and apoptosis of SGC7901 were inhibited by sorafenib. • Sorafenib treatment decreased phosphorylation activation of ERK protein. • Sorafenib increased pro-apoptosis protein expression. • ERK signals in SGC7901 are one of the mechanisms of sorafenib inhibiting gastric...

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Bibliographic Details
Published in:Environmental toxicology and pharmacology 2014-09, Vol.38 (2), p.438-443
Main Authors: Juan, Liu Wei, En, Lin Ming, Hao, Lin, Kai, Hong Ying, Ju, Huang
Format: Article
Language:English
Subjects:
Antineoplastic Agents - pharmacology
Apoptosis
Cell cycle
Cell Line, Tumor
Cell Movement - drug effects
Cell Proliferation - drug effects
Emergency
ERK signal pathway
Gastric cancer
Gene Expression Regulation, Neoplastic - drug effects
Humans
MAP Kinase Signaling System - drug effects
Microcystis - metabolism
Niacinamide - analogs & derivatives
Niacinamide - pharmacology
Phenylurea Compounds - pharmacology
Phosphorylation - drug effects
Protein Kinase Inhibitors - pharmacology
SGC7901
Stomach Neoplasms - drug therapy
Stomach Neoplasms - genetics
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Summary:Highlights • Migration, invasion and apoptosis of SGC7901 were inhibited by sorafenib. • Sorafenib treatment decreased phosphorylation activation of ERK protein. • Sorafenib increased pro-apoptosis protein expression. • ERK signals in SGC7901 are one of the mechanisms of sorafenib inhibiting gastric cancer.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2014.07.012