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Sorafenib regulating ERK signals pathway in gastric cancer cell

Highlights • Migration, invasion and apoptosis of SGC7901 were inhibited by sorafenib. • Sorafenib treatment decreased phosphorylation activation of ERK protein. • Sorafenib increased pro-apoptosis protein expression. • ERK signals in SGC7901 are one of the mechanisms of sorafenib inhibiting gastric...

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Published in:	Environmental toxicology and pharmacology 2014-09, Vol.38 (2), p.438-443
Main Authors:	Juan, Liu Wei, En, Lin Ming, Hao, Lin, Kai, Hong Ying, Ju, Huang
Format:	Article
Language:	English
Subjects:	Antineoplastic Agents - pharmacology Apoptosis Cell cycle Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Emergency ERK signal pathway Gastric cancer Gene Expression Regulation, Neoplastic - drug effects Humans MAP Kinase Signaling System - drug effects Microcystis - metabolism Niacinamide - analogs & derivatives Niacinamide - pharmacology Phenylurea Compounds - pharmacology Phosphorylation - drug effects Protein Kinase Inhibitors - pharmacology SGC7901 Stomach Neoplasms - drug therapy Stomach Neoplasms - genetics
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creator	Juan, Liu Wei En, Lin Ming Hao, Lin Kai, Hong Ying Ju, Huang
description	Highlights • Migration, invasion and apoptosis of SGC7901 were inhibited by sorafenib. • Sorafenib treatment decreased phosphorylation activation of ERK protein. • Sorafenib increased pro-apoptosis protein expression. • ERK signals in SGC7901 are one of the mechanisms of sorafenib inhibiting gastric cancer.
doi_str_mv	10.1016/j.etap.2014.07.012
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subjects	Antineoplastic Agents - pharmacology Apoptosis Cell cycle Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Emergency ERK signal pathway Gastric cancer Gene Expression Regulation, Neoplastic - drug effects Humans MAP Kinase Signaling System - drug effects Microcystis - metabolism Niacinamide - analogs & derivatives Niacinamide - pharmacology Phenylurea Compounds - pharmacology Phosphorylation - drug effects Protein Kinase Inhibitors - pharmacology SGC7901 Stomach Neoplasms - drug therapy Stomach Neoplasms - genetics
title	Sorafenib regulating ERK signals pathway in gastric cancer cell
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