Why Does Enzyme Not Leach from Metal–Organic Frameworks (MOFs)? Unveiling the Interactions between an Enzyme Molecule and a MOF

The strong interactions between microperoxidase (MP-11) and Tb-mesoMOF were identified via Raman spectroscopic studies, which revealed that MP-11 molecules interact with the framework of Tb-mesoMOF through π···π interactions between the heme of MP-11 and the conjugated triazine and benzene rings in...

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Bibliographic Details
Published in:Inorganic chemistry 2014-10, Vol.53 (19), p.10006-10008
Main Authors: Chen, Yao, Han, Sungyub, Li, Xiao, Zhang, Zhenjie, Ma, Shengqian
Format: Article
Language:English
Subjects:
Models, Molecular
Molecular Structure
Organometallic Compounds - chemistry
Organometallic Compounds - metabolism
Peroxidases - chemistry
Peroxidases - metabolism
Terbium - chemistry
Terbium - metabolism
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Summary:The strong interactions between microperoxidase (MP-11) and Tb-mesoMOF were identified via Raman spectroscopic studies, which revealed that MP-11 molecules interact with the framework of Tb-mesoMOF through π···π interactions between the heme of MP-11 and the conjugated triazine and benzene rings in the organic ligand of Tb-mesoMOF. The strong interactions facilitate the retention of MP-11 molecules within the metal–organic framework (MOF) pores, which is in striking contrast with the severe leaching of MP-11 from MCM-41 due to the lack of specific interactions between enzyme molecules and the mesoporous silica material.
ISSN:0020-1669
1520-510X
DOI:10.1021/ic501062r