Atorvastatin exerts anti-nociceptive activity and decreases serum levels of high-sensitivity C-reactive protein and tumor necrosis factor-α in a rat endometriosis model

• Published in: Archives of gynecology and obstetrics 2014-11, Vol.290 (5), p.999-1006
• Main Authors: Simsek, Yavuz, Gul, Mehmet, Yilmaz, Ercan, Ozerol, Ibrahim Halil, Ozerol, Elif, Parlakpinar, Hakan
• Format: Article
• Language: English
• Subjects: Analgesics - administration & dosage; Animals; Atorvastatin Calcium; C-Reactive Protein - drug effects; C-Reactive Protein - metabolism; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Endocrinology; Endometriosis; Endometriosis - drug therapy; Endometriosis - pathology; Endometrium - transplantation; Female; Gynecologic Endocrinology and Reproductive Medicine; Gynecology; Heptanoic Acids - administration & dosage; Human Genetics; Humans; Leuprolide - administration & dosage; Medicine; Medicine & Public Health; Necrosis; Nociception - drug effects; Nociceptive Pain - drug therapy; Obstetrics/Perinatology/Midwifery; Pyrroles - administration & dosage; Rats; Rats, Wistar; Rodents; Treatment Outcome; Tumor Necrosis Factor-alpha - blood; Tumor Necrosis Factor-alpha - drug effects; Tumor necrosis factor-TNF
• ISSN: 0932-0067; 1432-0711
• DOI: 10.1007/s00404-014-3295-4

Purpose The purpose of this study was to examine the effects of atorvastatin in the treatment of experimental endometriosis. Methods Endometriosis was induced in 24 female rats. 4 weeks after the procedure dimensions of the foci were recorded. Rats were divided into three groups: in Group 1 ( n  = 8), a daily dose of 10 mg/kg atorvastatin was given for 14 days. In the second group ( n  = 8), a single dose of 1 mg/kg leuprolide acetate was injected intraperitoneally. The rats in Group 3 ( n  = 8) were received 1 mg/kg i.p. 0.9 % NaCl. At the end of the treatment, laparotomy was performed, and the dimensions of the endometriotic foci were recorded. Biochemical, histopathological and immunohistochemical studies were performed and nociception was compared in groups. Results Atorvastatin treatment exhibited significant analgesic activity in hot plate model ( P  = 0.022). The serum hs-CRP and tumor necrosis TNF-α levels were similar between the Group 2 and Group 3 ( P  > 0.05); however atorvastatin caused significant decrease in both serum markers. The histological and immunohistochemical scores were also found to be markedly lower in Group 1 and Group 2 ( P