Cell and biomolecule delivery for tissue repair and regeneration in the central nervous system

Tissue engineering frequently involves cells and scaffolds to replace damaged or diseased tissue. It originated, in part, as a means of effecting the delivery of biomolecules such as insulin or neurotrophic factors, given that cells are constitutive producers of such therapeutic agents. Thus cell de...

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Bibliographic Details
Published in:Journal of controlled release 2014-09, Vol.190, p.219-227
Main Authors: Elliott Donaghue, Irja, Tam, Roger, Sefton, Michael V, Shoichet, Molly S
Format: Article
Language:English
Subjects:
Central Nervous System - drug effects
Central Nervous System - physiology
Delayed-Action Preparations
Drug Carriers
Drug Delivery Systems
Humans
Hydrogel, Polyethylene Glycol Dimethacrylate
Microspheres
Nanoparticles
Nerve Regeneration - physiology
Polymers
Regeneration - drug effects
Tissue Engineering - methods
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Summary:Tissue engineering frequently involves cells and scaffolds to replace damaged or diseased tissue. It originated, in part, as a means of effecting the delivery of biomolecules such as insulin or neurotrophic factors, given that cells are constitutive producers of such therapeutic agents. Thus cell delivery is intrinsic to tissue engineering. Controlled release of biomolecules is also an important tool for enabling cell delivery since the biomolecules can enable cell engraftment, modulate inflammatory response or otherwise benefit the behavior of the delivered cells. We describe advances in cell and biomolecule delivery for tissue regeneration, with emphasis on the central nervous system (CNS). In the first section, the focus is on encapsulated cell therapy. In the second section, the focus is on biomolecule delivery in polymeric nano/microspheres and hydrogels for the nerve regeneration and endogenous cell stimulation. In the third section, the focus is on combination strategies of neural stem/progenitor cell or mesenchymal stem cell and biomolecule delivery for tissue regeneration and repair. In each section, the challenges and potential solutions associated with delivery to the CNS are highlighted.
ISSN:0168-3659
1873-4995
DOI:10.1016/j.jconrel.2014.05.040