Redefining normal bone and mineral clinical biochemistry reference intervals for healthy infants in Canada

Few normative data exist for routine clinical chemistry in healthy term infants, that is, during a time of rapid development. Biochemical markers are significantly affected by these physiological changes and the lack of appropriate reference intervals may impede diagnostics in infants. To define ref...

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Bibliographic Details
Published in:Clinical biochemistry 2014-10, Vol.47 (15), p.27-32
Main Authors: Gallo, Sina, Comeau, Kathyrn, Sharma, Atul, Vanstone, Catherine A., Agellon, Sherry, Mitchell, John, Weiler, Hope A., Rodd, Celia
Format: Article
Language:English
Subjects:
Alkaline Phosphatase - blood
Alkaline Phosphatase - urine
Bone Development - drug effects
Bone Development - genetics
Breast Feeding
Breastfed
Calcium
Calcium - blood
Calcium - urine
Canada
Cholecalciferol - administration & dosage
Creatinine
Creatinine - blood
Creatinine - urine
Female
Growth
Humans
Infant
Infant, Newborn
Infants
Male
Minerals
Minerals - blood
Minerals - urine
Normative
Phosphate
Phosphates - blood
Phosphates - urine
Reference Values
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Summary:Few normative data exist for routine clinical chemistry in healthy term infants, that is, during a time of rapid development. Biochemical markers are significantly affected by these physiological changes and the lack of appropriate reference intervals may impede diagnostics in infants. To define reference intervals for calcium, phosphate, creatinine, and alkaline phosphatase in infants from 1 to 12months of age. This was an unblinded secondary analysis of 132 breastfeeding infants participating in a vitamin D3 supplementation trial (400–1600IU/d) followed prospectively until 1year of age (NCT00381914). Serial non-fasting capillary and spot urine samples were collected for the measurement of plasma calcium, phosphate, creatinine, and alkaline phosphatase; urinary calcium, phosphate and creatinine (DxC600 Beckman Coulter); and whole-blood ionized calcium (ABL 725 Radiometer). All visits were conducted at McGill University in Montréal, Canada. All analytes changed significantly over time (p
ISSN:0009-9120
1873-2933
DOI:10.1016/j.clinbiochem.2014.07.012