Diffusion tensor imaging of white matter degeneration in Alzheimer’s disease and mild cognitive impairment

Highlights • White matter (WM) is affected early in Alzheimer’s disease (AD). • WM degeneration in early AD is partly independent of gray matter atrophy. • Longitudinal WM degeneration is related to Tau proteins measured in CSF. • WM degeneration is likely an important part of the AD pathogenesis....

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Bibliographic Details
Published in:Neuroscience 2014-09, Vol.276, p.206-215
Main Authors: Amlien, I.K, Fjell, A.M
Format: Article
Language:English
Subjects:
Alzheimer Disease - pathology
Alzheimer’s disease
Animals
Axons - pathology
Biomarkers
Cognitive Dysfunction - pathology
CSF biomarkers
Diffusion Tensor Imaging
Disease Progression
Gray Matter - pathology
Humans
mild cognitive impairment
Nerve Degeneration
Neurology
Tau proteins
tau Proteins - cerebrospinal fluid
Wallerian Degeneration
white matter
White Matter - pathology
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Description
Summary:Highlights • White matter (WM) is affected early in Alzheimer’s disease (AD). • WM degeneration in early AD is partly independent of gray matter atrophy. • Longitudinal WM degeneration is related to Tau proteins measured in CSF. • WM degeneration is likely an important part of the AD pathogenesis.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2014.02.017