Neuropsychiatric complications in a patient with Marfan syndrome

Marfan syndrome (MFS) is an autosomal dominant disorder of fibrillin-1 gene mutations, with the involvement of cardiovascular, skeletal, and ocular systems. In addition to physical abnormalities, MFS patients are also found to be susceptible to schizophrenia and other psychiatric conditions. Awarene...

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Bibliographic Details
Published in:Acta neuropsychiatrica 2013-08, Vol.25 (4), p.245-247
Main Authors: Lee, Chin-Pang, Chu, Chun-Lin, Liu, Chia-Yih, Chen, Chia-Hsiang
Format: Article
Language:English
Subjects:
Activities of daily living
Adjustment
Age
Aneurysms
Aortic dissection
Atherosclerosis
Blood clots
Case Report
Dystonia
Electroencephalography
Family medical history
Hospitalization
Marfan syndrome
Medical imaging
Medical records
Mental disorders
Mutation
Outpatient care facilities
Schizophrenia
Stroke
Tomography
Veins & arteries
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Summary:Marfan syndrome (MFS) is an autosomal dominant disorder of fibrillin-1 gene mutations, with the involvement of cardiovascular, skeletal, and ocular systems. In addition to physical abnormalities, MFS patients are also found to be susceptible to schizophrenia and other psychiatric conditions. Awareness of the association between MFS and psychiatric conditions would improve the clinical management of MFS patients to reduce the risk or even to prevent the development of psychiatric complications in MFS patients. Here, we describe a male MFS patient who manifested incoherent speech and impaired cognitive and social function at the age of 40 years. Results and conclusion His mental dysfunction could be attributed to his bilateral cerebral infarction, which is a neurovascular complication associated with MFS.
ISSN:0924-2708
1601-5215
DOI:10.1017/neu.2012.31