Genetic analysis of acetan biosynthesis in Acetobacter xylinum : DNA sequence analysis of the aceM gene encoding an UDP-glucose dehydrogenase

Analysis of the nucleotide sequence of a 1592 bp region of Acetobacter xylinum genomic DNA involved in acetan biosynthesis revealed the presence of an open-reading frame (aceM) encoding a protein of 449 amino acids with a molecular weight of 48.5 kDa. The deduced amino acid sequence of aceM displaye...

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Bibliographic Details
Published in:Biotechnology letters 1997-05, Vol.19 (5), p.469-474
Main Authors: GRIFFIN, A. M, EDWARDS, K. J, MORRIS, V. J, GASSON, M. J
Format: Article
Language:English
Subjects:
Acetobacter xylinum
Amino acids
Biological and medical sciences
Biology of microorganisms of confirmed or potential industrial interest
Biosynthesis
Biotechnology
Dehydrogenase
Deoxyribonucleic acid
DNA
Fundamental and applied biological sciences. Psychology
Genetics
Mission oriented research
Proteins
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Summary:Analysis of the nucleotide sequence of a 1592 bp region of Acetobacter xylinum genomic DNA involved in acetan biosynthesis revealed the presence of an open-reading frame (aceM) encoding a protein of 449 amino acids with a molecular weight of 48.5 kDa. The deduced amino acid sequence of aceM displayed high homology to the protein sequences of genes encoding UDP-glucose dehydrogenase (UGDH) activities from other organisms. AceM is likely to encode the UGDH involved in the biosynthesis of UDP-glucuronic acid required for acetanbiosynthesis.[PUBLICATION ABSTRACT]
ISSN:0141-5492
1573-6776
DOI:10.1023/A:1018304412944