Antidepressant Adherence and Risk of Coronary Artery Disease Hospitalizations in Older and Younger Adults with Depression

Objectives To assess whether the relationship between antidepressant adherence and coronary artery disease (CAD) hospitalizations varied between older and younger adults with depression. Design Retrospective cohort study. Setting Department of Veterans Affairs outpatient clinics nationwide. Particip...

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Bibliographic Details
Published in:Journal of the American Geriatrics Society (JAGS) 2014-07, Vol.62 (7), p.1238-1245
Main Authors: Cooper, Denise C., Trivedi, Ranak B., Nelson, Karin M., Reiber, Gayle E., Eugenio, Evercita C., Beaver, Kristine A., Fan, Vincent S.
Format: Article
Language:English
Subjects:
adherence
Adult and adolescent clinical studies
Aged
Antidepressants
Antidepressive Agents - therapeutic use
Biological and medical sciences
Cardiology. Vascular system
Cardiovascular disease
Cohort Studies
Compliance
coronary artery disease
Coronary Artery Disease - complications
Coronary Artery Disease - therapy
Coronary Disease
Coronary heart disease
Depression
Depression - complications
Depression - drug therapy
Female
General aspects
Geriatrics
Heart
Hospitalization
Hospitalization - statistics & numerical data
hospitalizations
Humans
Male
Medical sciences
Medication Adherence - statistics & numerical data
Mental depression
Middle Aged
Mood disorders
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Retrospective Studies
Risk
Risk factors
Young adults
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Summary:Objectives To assess whether the relationship between antidepressant adherence and coronary artery disease (CAD) hospitalizations varied between older and younger adults with depression. Design Retrospective cohort study. Setting Department of Veterans Affairs outpatient clinics nationwide. Participants Chronically depressed individuals (n = 50,261; aged 20–97) who had been prescribed an antidepressant were identified from records indicating an outpatient clinic visit for depression (index depression visit) during fiscal years 2009 and 2010. Individuals were considered chronically depressed if they had had prior depression visits and treatment for depression within the previous 4 months. The sample was age‐stratified into younger (
ISSN:0002-8614
1532-5415
DOI:10.1111/jgs.12849