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Antidepressant Adherence and Risk of Coronary Artery Disease Hospitalizations in Older and Younger Adults with Depression
Objectives To assess whether the relationship between antidepressant adherence and coronary artery disease (CAD) hospitalizations varied between older and younger adults with depression. Design Retrospective cohort study. Setting Department of Veterans Affairs outpatient clinics nationwide. Particip...
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| Published in: | Journal of the American Geriatrics Society (JAGS) 2014-07, Vol.62 (7), p.1238-1245 |
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| Main Authors: | , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c5579-850d449762c5e520d7ffc4414c6492d737cbac9ecc1510fad9301c2ffc365f03 |
| container_end_page | 1245 |
| container_issue | 7 |
| container_start_page | 1238 |
| container_title | Journal of the American Geriatrics Society (JAGS) |
| container_volume | 62 |
| creator | Cooper, Denise C. Trivedi, Ranak B. Nelson, Karin M. Reiber, Gayle E. Eugenio, Evercita C. Beaver, Kristine A. Fan, Vincent S. |
| description | Objectives
To assess whether the relationship between antidepressant adherence and coronary artery disease (CAD) hospitalizations varied between older and younger adults with depression.
Design
Retrospective cohort study.
Setting
Department of Veterans Affairs outpatient clinics nationwide.
Participants
Chronically depressed individuals (n = 50,261; aged 20–97) who had been prescribed an antidepressant were identified from records indicating an outpatient clinic visit for depression (index depression visit) during fiscal years 2009 and 2010. Individuals were considered chronically depressed if they had had prior depression visits and treatment for depression within the previous 4 months. The sample was age‐stratified into younger ( |
| doi_str_mv | 10.1111/jgs.12849 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1609509449</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1551641572</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5579-850d449762c5e520d7ffc4414c6492d737cbac9ecc1510fad9301c2ffc365f03</originalsourceid><addsrcrecordid>eNqN0kFvFCEYBmBiNHatHvwDhsSY6GFaYIAZjtNtu6upNtFNjF4IBaZlOwsrzKRdf71sZ1sTE6NcIOH5-AIvALzE6ADncbi8TAeY1FQ8AhPMSlIwitljMEEIkaLmmO6BZyktEcIE1fVTsEdoLfImmoBN43tn7DralJTvYWOubLReW6i8gZ9duoahhdMQg1dxA5vY2zwdu2RVsnAe0tr1qnM_Ve-CT9B5eN4ZG--qv4XBX-Z1Y4auT_DG9VfweGyV8XPwpFVdsi928z5YnJ4spvPi7Hz2ftqcFZqxShQ1Q4ZSUXGimWUEmaptNaWYak4FMVVZ6QulhdUaM4xaZUSJsCYZlZy1qNwHb8dj1zH8GGzq5colbbtOeRuGJDFHgiGRW_ybMoZ5ftmK_AelFSt5VfFMX_9Bl2GIPl95qxiqSS226t2odAwpRdvKdXSr_OQSI7kNWeaQ5V3I2b7anThcrKx5kPepZvBmB1TSqmuj8tql3y5_ifwpcHaHo7txnd38vaP8MPty37oYK1zq7e1DhYrXkucomPz6aSaP-HS-IKcf5ffyF9-XzA4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1545082896</pqid></control><display><type>article</type><title>Antidepressant Adherence and Risk of Coronary Artery Disease Hospitalizations in Older and Younger Adults with Depression</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Cooper, Denise C. ; Trivedi, Ranak B. ; Nelson, Karin M. ; Reiber, Gayle E. ; Eugenio, Evercita C. ; Beaver, Kristine A. ; Fan, Vincent S.</creator><creatorcontrib>Cooper, Denise C. ; Trivedi, Ranak B. ; Nelson, Karin M. ; Reiber, Gayle E. ; Eugenio, Evercita C. ; Beaver, Kristine A. ; Fan, Vincent S.</creatorcontrib><description>Objectives
To assess whether the relationship between antidepressant adherence and coronary artery disease (CAD) hospitalizations varied between older and younger adults with depression.
Design
Retrospective cohort study.
Setting
Department of Veterans Affairs outpatient clinics nationwide.
Participants
Chronically depressed individuals (n = 50,261; aged 20–97) who had been prescribed an antidepressant were identified from records indicating an outpatient clinic visit for depression (index depression visit) during fiscal years 2009 and 2010. Individuals were considered chronically depressed if they had had prior depression visits and treatment for depression within the previous 4 months. The sample was age‐stratified into younger (<65) and older (≥65) groups.
Measurements
After the index depression visit, medication possession ratios were calculated from pharmacy refill data to determine whether participants had 80% or greater adherence to antidepressant refills during a 6‐month treatment observation period. International Classification of Diseases, Ninth Revision, codes were used to derive CAD‐related hospitalizations during the follow‐up period. Mean follow‐up was 24 months. Data were analyzed using Cox proportional hazard models.
Results
Older participants with 80% or greater antidepressant adherence had 26% lower risk of CAD hospitalizations (hazard ratio = 0.74, 95% confidence interval = 0.60–0.93). Antidepressant adherence was not significantly related to CAD hospitalizations in younger adults.
Conclusion
Older adults with chronic depression with 80% or greater antidepressant adherence had significantly lower risk of CAD hospitalizations at follow‐up than those with less than 80% adherence. These preliminary results suggest that older adults with depression may derive cardiovascular benefits from clinical efforts to increase antidepressant adherence.</description><identifier>ISSN: 0002-8614</identifier><identifier>EISSN: 1532-5415</identifier><identifier>DOI: 10.1111/jgs.12849</identifier><identifier>PMID: 24890000</identifier><identifier>CODEN: JAGSAF</identifier><language>eng</language><publisher>Hoboken, NJ: Blackwell Publishing Ltd</publisher><subject>adherence ; Adult and adolescent clinical studies ; Aged ; Antidepressants ; Antidepressive Agents - therapeutic use ; Biological and medical sciences ; Cardiology. Vascular system ; Cardiovascular disease ; Cohort Studies ; Compliance ; coronary artery disease ; Coronary Artery Disease - complications ; Coronary Artery Disease - therapy ; Coronary Disease ; Coronary heart disease ; Depression ; Depression - complications ; Depression - drug therapy ; Female ; General aspects ; Geriatrics ; Heart ; Hospitalization ; Hospitalization - statistics & numerical data ; hospitalizations ; Humans ; Male ; Medical sciences ; Medication Adherence - statistics & numerical data ; Mental depression ; Middle Aged ; Mood disorders ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Retrospective Studies ; Risk ; Risk factors ; Young adults</subject><ispartof>Journal of the American Geriatrics Society (JAGS), 2014-07, Vol.62 (7), p.1238-1245</ispartof><rights>2014, Copyright the Authors Journal compilation © 2014, The American Geriatrics Society</rights><rights>2015 INIST-CNRS</rights><rights>2014, Copyright the Authors Journal compilation © 2014, The American Geriatrics Society.</rights><rights>2014 American Geriatrics Society and Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5579-850d449762c5e520d7ffc4414c6492d737cbac9ecc1510fad9301c2ffc365f03</citedby><cites>FETCH-LOGICAL-c5579-850d449762c5e520d7ffc4414c6492d737cbac9ecc1510fad9301c2ffc365f03</cites><orcidid>0000-0002-4878-9480 ; 0000-0002-6178-1117 ; 0000-0002-0484-4580</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27911,27912</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28616141$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24890000$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cooper, Denise C.</creatorcontrib><creatorcontrib>Trivedi, Ranak B.</creatorcontrib><creatorcontrib>Nelson, Karin M.</creatorcontrib><creatorcontrib>Reiber, Gayle E.</creatorcontrib><creatorcontrib>Eugenio, Evercita C.</creatorcontrib><creatorcontrib>Beaver, Kristine A.</creatorcontrib><creatorcontrib>Fan, Vincent S.</creatorcontrib><title>Antidepressant Adherence and Risk of Coronary Artery Disease Hospitalizations in Older and Younger Adults with Depression</title><title>Journal of the American Geriatrics Society (JAGS)</title><addtitle>J Am Geriatr Soc</addtitle><description>Objectives
To assess whether the relationship between antidepressant adherence and coronary artery disease (CAD) hospitalizations varied between older and younger adults with depression.
Design
Retrospective cohort study.
Setting
Department of Veterans Affairs outpatient clinics nationwide.
Participants
Chronically depressed individuals (n = 50,261; aged 20–97) who had been prescribed an antidepressant were identified from records indicating an outpatient clinic visit for depression (index depression visit) during fiscal years 2009 and 2010. Individuals were considered chronically depressed if they had had prior depression visits and treatment for depression within the previous 4 months. The sample was age‐stratified into younger (<65) and older (≥65) groups.
Measurements
After the index depression visit, medication possession ratios were calculated from pharmacy refill data to determine whether participants had 80% or greater adherence to antidepressant refills during a 6‐month treatment observation period. International Classification of Diseases, Ninth Revision, codes were used to derive CAD‐related hospitalizations during the follow‐up period. Mean follow‐up was 24 months. Data were analyzed using Cox proportional hazard models.
Results
Older participants with 80% or greater antidepressant adherence had 26% lower risk of CAD hospitalizations (hazard ratio = 0.74, 95% confidence interval = 0.60–0.93). Antidepressant adherence was not significantly related to CAD hospitalizations in younger adults.
Conclusion
Older adults with chronic depression with 80% or greater antidepressant adherence had significantly lower risk of CAD hospitalizations at follow‐up than those with less than 80% adherence. These preliminary results suggest that older adults with depression may derive cardiovascular benefits from clinical efforts to increase antidepressant adherence.</description><subject>adherence</subject><subject>Adult and adolescent clinical studies</subject><subject>Aged</subject><subject>Antidepressants</subject><subject>Antidepressive Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular disease</subject><subject>Cohort Studies</subject><subject>Compliance</subject><subject>coronary artery disease</subject><subject>Coronary Artery Disease - complications</subject><subject>Coronary Artery Disease - therapy</subject><subject>Coronary Disease</subject><subject>Coronary heart disease</subject><subject>Depression</subject><subject>Depression - complications</subject><subject>Depression - drug therapy</subject><subject>Female</subject><subject>General aspects</subject><subject>Geriatrics</subject><subject>Heart</subject><subject>Hospitalization</subject><subject>Hospitalization - statistics & numerical data</subject><subject>hospitalizations</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medication Adherence - statistics & numerical data</subject><subject>Mental depression</subject><subject>Middle Aged</subject><subject>Mood disorders</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Retrospective Studies</subject><subject>Risk</subject><subject>Risk factors</subject><subject>Young adults</subject><issn>0002-8614</issn><issn>1532-5415</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqN0kFvFCEYBmBiNHatHvwDhsSY6GFaYIAZjtNtu6upNtFNjF4IBaZlOwsrzKRdf71sZ1sTE6NcIOH5-AIvALzE6ADncbi8TAeY1FQ8AhPMSlIwitljMEEIkaLmmO6BZyktEcIE1fVTsEdoLfImmoBN43tn7DralJTvYWOubLReW6i8gZ9duoahhdMQg1dxA5vY2zwdu2RVsnAe0tr1qnM_Ve-CT9B5eN4ZG--qv4XBX-Z1Y4auT_DG9VfweGyV8XPwpFVdsi928z5YnJ4spvPi7Hz2ftqcFZqxShQ1Q4ZSUXGimWUEmaptNaWYak4FMVVZ6QulhdUaM4xaZUSJsCYZlZy1qNwHb8dj1zH8GGzq5colbbtOeRuGJDFHgiGRW_ybMoZ5ftmK_AelFSt5VfFMX_9Bl2GIPl95qxiqSS226t2odAwpRdvKdXSr_OQSI7kNWeaQ5V3I2b7anThcrKx5kPepZvBmB1TSqmuj8tql3y5_ifwpcHaHo7txnd38vaP8MPty37oYK1zq7e1DhYrXkucomPz6aSaP-HS-IKcf5ffyF9-XzA4</recordid><startdate>201407</startdate><enddate>201407</enddate><creator>Cooper, Denise C.</creator><creator>Trivedi, Ranak B.</creator><creator>Nelson, Karin M.</creator><creator>Reiber, Gayle E.</creator><creator>Eugenio, Evercita C.</creator><creator>Beaver, Kristine A.</creator><creator>Fan, Vincent S.</creator><general>Blackwell Publishing Ltd</general><general>Wiley-Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>ASE</scope><scope>FPQ</scope><scope>K6X</scope><orcidid>https://orcid.org/0000-0002-4878-9480</orcidid><orcidid>https://orcid.org/0000-0002-6178-1117</orcidid><orcidid>https://orcid.org/0000-0002-0484-4580</orcidid></search><sort><creationdate>201407</creationdate><title>Antidepressant Adherence and Risk of Coronary Artery Disease Hospitalizations in Older and Younger Adults with Depression</title><author>Cooper, Denise C. ; Trivedi, Ranak B. ; Nelson, Karin M. ; Reiber, Gayle E. ; Eugenio, Evercita C. ; Beaver, Kristine A. ; Fan, Vincent S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5579-850d449762c5e520d7ffc4414c6492d737cbac9ecc1510fad9301c2ffc365f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>adherence</topic><topic>Adult and adolescent clinical studies</topic><topic>Aged</topic><topic>Antidepressants</topic><topic>Antidepressive Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular disease</topic><topic>Cohort Studies</topic><topic>Compliance</topic><topic>coronary artery disease</topic><topic>Coronary Artery Disease - complications</topic><topic>Coronary Artery Disease - therapy</topic><topic>Coronary Disease</topic><topic>Coronary heart disease</topic><topic>Depression</topic><topic>Depression - complications</topic><topic>Depression - drug therapy</topic><topic>Female</topic><topic>General aspects</topic><topic>Geriatrics</topic><topic>Heart</topic><topic>Hospitalization</topic><topic>Hospitalization - statistics & numerical data</topic><topic>hospitalizations</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medication Adherence - statistics & numerical data</topic><topic>Mental depression</topic><topic>Middle Aged</topic><topic>Mood disorders</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Retrospective Studies</topic><topic>Risk</topic><topic>Risk factors</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cooper, Denise C.</creatorcontrib><creatorcontrib>Trivedi, Ranak B.</creatorcontrib><creatorcontrib>Nelson, Karin M.</creatorcontrib><creatorcontrib>Reiber, Gayle E.</creatorcontrib><creatorcontrib>Eugenio, Evercita C.</creatorcontrib><creatorcontrib>Beaver, Kristine A.</creatorcontrib><creatorcontrib>Fan, Vincent S.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>British Nursing Index</collection><jtitle>Journal of the American Geriatrics Society (JAGS)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cooper, Denise C.</au><au>Trivedi, Ranak B.</au><au>Nelson, Karin M.</au><au>Reiber, Gayle E.</au><au>Eugenio, Evercita C.</au><au>Beaver, Kristine A.</au><au>Fan, Vincent S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antidepressant Adherence and Risk of Coronary Artery Disease Hospitalizations in Older and Younger Adults with Depression</atitle><jtitle>Journal of the American Geriatrics Society (JAGS)</jtitle><addtitle>J Am Geriatr Soc</addtitle><date>2014-07</date><risdate>2014</risdate><volume>62</volume><issue>7</issue><spage>1238</spage><epage>1245</epage><pages>1238-1245</pages><issn>0002-8614</issn><eissn>1532-5415</eissn><coden>JAGSAF</coden><abstract>Objectives
To assess whether the relationship between antidepressant adherence and coronary artery disease (CAD) hospitalizations varied between older and younger adults with depression.
Design
Retrospective cohort study.
Setting
Department of Veterans Affairs outpatient clinics nationwide.
Participants
Chronically depressed individuals (n = 50,261; aged 20–97) who had been prescribed an antidepressant were identified from records indicating an outpatient clinic visit for depression (index depression visit) during fiscal years 2009 and 2010. Individuals were considered chronically depressed if they had had prior depression visits and treatment for depression within the previous 4 months. The sample was age‐stratified into younger (<65) and older (≥65) groups.
Measurements
After the index depression visit, medication possession ratios were calculated from pharmacy refill data to determine whether participants had 80% or greater adherence to antidepressant refills during a 6‐month treatment observation period. International Classification of Diseases, Ninth Revision, codes were used to derive CAD‐related hospitalizations during the follow‐up period. Mean follow‐up was 24 months. Data were analyzed using Cox proportional hazard models.
Results
Older participants with 80% or greater antidepressant adherence had 26% lower risk of CAD hospitalizations (hazard ratio = 0.74, 95% confidence interval = 0.60–0.93). Antidepressant adherence was not significantly related to CAD hospitalizations in younger adults.
Conclusion
Older adults with chronic depression with 80% or greater antidepressant adherence had significantly lower risk of CAD hospitalizations at follow‐up than those with less than 80% adherence. These preliminary results suggest that older adults with depression may derive cardiovascular benefits from clinical efforts to increase antidepressant adherence.</abstract><cop>Hoboken, NJ</cop><pub>Blackwell Publishing Ltd</pub><pmid>24890000</pmid><doi>10.1111/jgs.12849</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-4878-9480</orcidid><orcidid>https://orcid.org/0000-0002-6178-1117</orcidid><orcidid>https://orcid.org/0000-0002-0484-4580</orcidid></addata></record> |
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| ispartof | Journal of the American Geriatrics Society (JAGS), 2014-07, Vol.62 (7), p.1238-1245 |
| issn | 0002-8614 1532-5415 |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | adherence Adult and adolescent clinical studies Aged Antidepressants Antidepressive Agents - therapeutic use Biological and medical sciences Cardiology. Vascular system Cardiovascular disease Cohort Studies Compliance coronary artery disease Coronary Artery Disease - complications Coronary Artery Disease - therapy Coronary Disease Coronary heart disease Depression Depression - complications Depression - drug therapy Female General aspects Geriatrics Heart Hospitalization Hospitalization - statistics & numerical data hospitalizations Humans Male Medical sciences Medication Adherence - statistics & numerical data Mental depression Middle Aged Mood disorders Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Retrospective Studies Risk Risk factors Young adults |
| title | Antidepressant Adherence and Risk of Coronary Artery Disease Hospitalizations in Older and Younger Adults with Depression |
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