PF1092A, B and C, new nonsteroidal progesterone receptor ligands produced by Penicillium oblatum. 1. Taxonomy of producing strain, fermentation, isolation and biological activities

Three new nonsteroidal progesterone receptor ligands, PF1092A, B and C, have been isolated from Penicillium oblatum. They were purified from the solid cultures of rice media using ethyl acetate extraction, silica gel and Sephadex LH-20 column chromatographies, and crystallization. All three ligands...

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Bibliographic Details
Published in:Journal of antibiotics 1997-04, Vol.50 (4), p.304-308
Main Authors: Tabata, Y, Miike, N, Hatsu, M, Kurata, Y, Yaguchi, T, Someya, A, Miyadoh, S, Hoshiko, S, Tsuruoka, T, Omoto, S
Format: Article
Language:English
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Summary:Three new nonsteroidal progesterone receptor ligands, PF1092A, B and C, have been isolated from Penicillium oblatum. They were purified from the solid cultures of rice media using ethyl acetate extraction, silica gel and Sephadex LH-20 column chromatographies, and crystallization. All three ligands competitively inhibited [ super(3)H]-progesterone binding to porcine uteri cytosol preparations with IC sub(50) of 3.0 x 10 nM (PF1092A), 2.2 x 10 super(2) nM (PF1092B) and 2.2 x 10 super(3) nM (PF1092C).
ISSN:0021-8820
DOI:10.7164/antibiotics.50.304